油症和玉成病患者组织中的多氯联苯、多氯喹啉和多氯二苯并呋喃
PCBs, PCQs and PCDFs in tissues of yusho and yu-cheng patients.
作者信息
Miyata H, Fukushima S, Kashimoto T, Kunita N
出版信息
Environ Health Perspect. 1985 Feb;59:67-72. doi: 10.1289/ehp.59-1568097.
All five samples of oil involved in the recent yu-cheng outbreak were heavily contaminated with PCBs, PCQs and PCDFs at levels, on the average, of 62, 20 and 0.14 ppm, respectively. The samples not only had roughly one-tenth of the contamination by PCBs, PCQs and PCDFs but also three to four times lower ratios of PCQs and PCDFs to PCBs than samples of oil involved in yusho in Japan. PCBs, PCQs and PCDFs present were all composed of similar congeners to the ones found in the yusho specimens, though some variation of the component ratios of PCBs and PCDFs were observed. On the other hand, five patients with yusho who died 1 to 10 years following poisoning had markedly higher tissue levels of PCDFs and PCQs than did a worker occupationally exposed to PCBs. Taking great differences in the process of the healing and the tissue levels of PCBs, PCQs and PCDFs between the two poisoning cases into consideration, PCDFs and PCQs--especially the former--and not PCBs are deduced to be strongly associated with the development of yusho.
近期油症爆发所涉及的全部五个油样均被多氯联苯（PCBs）、多氯喹啉（PCQs）和多氯二苯并呋喃（PCDFs）严重污染，平均含量分别为62 ppm、20 ppm和0.14 ppm。这些样品中PCBs、PCQs和PCDFs的污染程度不仅约为日本油症所涉油样的十分之一，而且PCQs和PCDFs与PCBs的比例也比日本油症所涉油样低三到四倍。尽管观察到PCBs和PCDFs的成分比例存在一些差异，但所存在的PCBs、PCQs和PCDFs均由与在油症标本中发现的类似同系物组成。另一方面，五名在中毒后1至10年死亡的油症患者的PCDFs和PCQs组织水平明显高于一名职业性接触PCBs的工人。考虑到这两起中毒病例在康复过程以及PCBs、PCQs和PCDFs组织水平上的巨大差异，可以推断PCDFs和PCQs——尤其是前者——而非PCBs与油症的发展密切相关。
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