油症和玉成病患者血液中的多氯联苯、多氯喹啉和多氯二苯并呋喃
PCBs, PCQs and PCDFs in blood of yusho and yu-cheng patients.
作者信息
Kashimoto T, Miyata H, Fukushima S, Kunita N, Ohi G, Tung T C
出版信息
Environ Health Perspect. 1985 Feb;59:73-8. doi: 10.1289/ehp.59-1568089.
Individual blood samples obtained from yusho and yu-cheng patients who had been poisoned by ingesting contaminated cooking oils, from workers occupationally exposed to polychlorinated biphenyls (PCBs) and from unexposed individuals were analyzed for PCBs, polychlorinated quaterphenyls (PCQs) and polychlorinated dibenzofurans (PCDFs) by gas chromatography and mass spectrometry. PCBs were found in the blood of all samples. PCQs were detected in the blood of 54 of 56 living yusho patients 11 years after the outbreak, and in all yu-cheng patients 6 months following poisoning. These facts indicate that the presence of PCQs in the blood was a good mark of past ingestion of the toxic oil. In the yu-cheng cases, PCDFs as well as PCBs and PCQs were detected in all blood samples. These identified isomers have been reported to be remarkably highly toxic compounds, i.e., both the 2,3,7,8-tetrachlorinated and 2,3,4,7,8-pentachlorinated compounds are toxicologically hundreds to thousands of times more toxic than PCB. In view of the high toxicity of PCDFs found in the yu-cheng patients' blood, we must deduce that they are the primary causal agents of yusho as well as of the yu-cheng incident.
对从因摄入受污染食用油而中毒的油症和油症患者、职业接触多氯联苯（PCBs）的工人以及未接触者身上采集的个体血样，采用气相色谱和质谱法分析其中的多氯联苯、多氯四联苯（PCQs）和多氯二苯并呋喃（PCDFs）。在所有样本的血液中均检测到多氯联苯。在油症爆发11年后，56名在世的油症患者中有54人的血液中检测到多氯四联苯，在油症患者中毒6个月后的所有血液样本中也检测到多氯四联苯。这些事实表明，血液中多氯四联苯的存在是过去摄入有毒油的一个良好标志。在油症病例中，所有血液样本中均检测到多氯二苯并呋喃以及多氯联苯和多氯四联苯。据报道，这些已鉴定出的异构体是剧毒化合物，即2,3,7,8 - 四氯化合物和2,3,4,7,8 - 五氯化合物在毒理学上的毒性比多氯联苯高数百至数千倍。鉴于在油症患者血液中发现的多氯二苯并呋喃具有高毒性，我们必须推断它们是油症以及油症事件的主要致病因素。
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