Ng I-Son, Wang Po-Hsiang, Ting Wan-Wen, Juo Jiun-Jang
Department of Chemical Engineering, National Cheng Kung University, Tainan 70101, Taiwan, Republic of China.
Department of Chemical Engineering and Materials Engineering, National Central University, Taoyuan 32001, Taiwan, Republic of China; Graduate Institute of Environmental Engineering, National Central University, Taoyuan 32001, Taiwan, Republic of China.
Trends Biotechnol. 2025 Feb;43(2):270-273. doi: 10.1016/j.tibtech.2024.08.006. Epub 2024 Aug 29.
One-pot enzymatic synthesis is flourishing in synthetic chemistry, heralding a sustainable and green era. Recent advancements enable the creation of complex enzymatic prosthetic groups and regeneration of enzymatic cofactors such as S-adenosylmethionine. The next frontier is to develop the effective and innovative cofactors for essential micronutrients, metabolic modulators, and biomedicines.
一锅法酶促合成在合成化学领域蓬勃发展，开创了一个可持续的绿色时代。最近的进展使得复杂的酶促辅基得以构建，以及诸如S-腺苷甲硫氨酸等酶辅因子的再生成为可能。下一个前沿领域是为必需的微量营养素、代谢调节剂和生物药物开发有效且创新的辅因子。
