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利用印度南安达曼的褐藻罗森文藻的水提物合成的磁铁矿纳米粒子的抗癌功效。

Anticancer efficacy of magnetite nanoparticles synthesized using aqueous extract of brown seaweed Rosenvingea intricata, South Andaman, India.

机构信息

Atal Centre for Ocean Science and Technology for Islands (ACOSTI), National Institute of Ocean Technology (NIOT), Port Blair, India.

Marine Biotechnology Division, Ministry of Earth Sciences, National Institute of Ocean Technology (NIOT), Goverment of India, Pallikaranai, Chennai, India.

出版信息

Sci Rep. 2024 Aug 31;14(1):20255. doi: 10.1038/s41598-024-67820-1.

DOI:10.1038/s41598-024-67820-1
PMID:39215065
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11364866/
Abstract

Cancer is a global issue and hence various efforts are being made. Iron oxide is considered a significant biochemical agent in the biomedical arena for cancer treatment. Marine macroalgae-mediated iron oxides especially, magnetite (FeO) nanoparticles (NPs) are a prospective alternative to diagnose and treat cancer owing to their fluorescent and magnetic properties. We intend to appraise the usability of the aqueous extract of Rosenvingea intricata (R. intricata) in FeO NPs synthesis and to study their cytotoxic effects against human hepatocarcinoma (Hep3B) and pancreatic (PANC1) cancer cells. In the present study, R. intricata were collected from the coastal region of South Andaman, India. Aqueous extracts of R. intricata were utilized to synthesize FeO NPs via the co-precipitation method. Phycosynthesized FeO NPs exhibited wide peak at 400-600 nm from ultraviolet-visible diffused reflectance spectroscopic analysis which validated the formation of NPs. Band edge emission peak at 660 nm in fluorescent spectra confirmed the quantum confinement in FeO NPs. Fourier transform infrared spectroscopy confirmed the role of R. intricata as a capping and reducing agent with functional groups such as O-H, C-H, C=O, N=O, C=C, C-O, C-N, and C-S arising from amino acids, polysaccharides, aliphatic hydrocarbons, esters, amides, lignins, alkanes, aliphatic amines, and sulfates. Physicochemical properties such as crystallite size (14.36 nm), hydrodynamic size (84.6 nm), irregular morphology, elemental composition, particle size (125 nm), crystallinity, and saturation magnetization (0.90007 emu/g) were obtained from x-ray diffractometer, dynamic light scattering, scanning electron microscopy, energy dispersive x-ray spectrometer, high-resolution transmission electron microscopy, selected area electron diffraction and vibrating sample magnetometer techniques, respectively. The cell viability showed dose-dependent cytotoxic effects and enhanced the apoptosis against Hep3B and PANC1 cancer cells. R. intricata extract capped FeO NPs could be the most appropriate and effective nanomaterial for cancer treatment and management.

摘要

癌症是一个全球性问题，因此正在做出各种努力。氧化铁被认为是生物医学领域治疗癌症的重要生化试剂。由于具有荧光和磁性特性，海洋大型藻类介导的氧化铁，特别是磁铁矿 (FeO) 纳米颗粒 (NPs)，是诊断和治疗癌症的有前途的替代方法。我们旨在评估罗森文藻 (Rosenvingea intricata，R. intricata) 水提物在 FeO NPs 合成中的可用性，并研究其对人肝癌 (Hep3B) 和胰腺 (PANC1) 癌细胞的细胞毒性作用。在本研究中，从印度南安达曼沿海地区采集了 R. intricata。通过共沉淀法利用 R. intricata 的水提物合成了 FeO NPs。通过紫外-可见漫反射光谱分析，合成的 FeO NPs 在 400-600nm 处显示出宽峰，这验证了 NPs 的形成。荧光光谱中的能带边缘发射峰在 660nm 处证实了 FeO NPs 中的量子限制。傅里叶变换红外光谱证实了 R. intricata 作为具有来自氨基酸、多糖、脂肪族烃、酯、酰胺、木质素、烷烃、脂肪族胺和硫酸盐的 O-H、C-H、C=O、N=O、C=C、C-O、C-N 和 C-S 等官能团的封端和还原剂的作用。通过 X 射线衍射仪、动态光散射、扫描电子显微镜、能量色散 X 射线光谱仪、高分辨率透射电子显微镜、选区电子衍射和振动样品磁强计技术分别获得了物理化学性质，如晶粒尺寸 (14.36nm)、水动力尺寸 (84.6nm)、不规则形态、元素组成、粒径 (125nm)、结晶度和饱和磁化强度 (0.90007emu/g)。细胞活力显示出剂量依赖性的细胞毒性作用，并增强了对 Hep3B 和 PANC1 癌细胞的凋亡作用。R. intricata 提取物包覆的 FeO NPs 可能是治疗和管理癌症的最合适和最有效的纳米材料。

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