Li Chen, Jiang Xianjie, Zhang Sheng, Wang Tianbo, Liu Xiaohan, Zhang Yue, Huang Gang, Zhang Xiaogang, Xu Junbo, Jin Zhongmin
School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.
The third people's hospital of Chengdu (Affiliated hospital of Southwest Jiaotong University), Chengdu 610031, P. R. China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2024 Aug 25;41(4):782-789. doi: 10.7507/1001-5515.202312070.
To investigate the biomechanical effects of direct ventricular assistance and explore the optimal loading mode, this study established a left ventricular model of heart failure patients based on the finite element method. It proposed a loading mode that maintains peak pressure compression, and compared it with the traditional sinusoidal loading mode from both hemodynamic and biomechanical perspectives. The results showed that both modes significantly improved hemodynamic parameters, with ejection fraction increased from a baseline of 29.33% to 37.32% and 37.77%, respectively, while peak pressure, stroke volume, and stroke work parameters also increased. Additionally, both modes showed improvements in stress concentration and excessive fiber strain. Moreover, considering the phase error of the assist device's working cycle, the proposed assist mode in this study was less affected. Therefore, this research may provide theoretical support for the design and optimization of direct ventricular assist devices.
为研究直接心室辅助的生物力学效应并探索最佳加载模式，本研究基于有限元方法建立了心力衰竭患者的左心室模型。提出了一种维持峰值压力压缩的加载模式，并从血流动力学和生物力学角度将其与传统正弦加载模式进行比较。结果表明，两种模式均显著改善了血流动力学参数，射血分数分别从基线的29.33%提高到37.32%和37.77%，同时峰值压力、每搏输出量和每搏功参数也有所增加。此外，两种模式在应力集中和纤维应变过大方面均有改善。而且，考虑到辅助装置工作周期的相位误差，本研究提出的辅助模式受影响较小。因此，本研究可为直接心室辅助装置的设计和优化提供理论支持。
