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德累斯顿质子治疗设施的研究束流线:可用基础设施与实验能力。

The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities.

作者信息

Horst Felix, Bodenstein Elisabeth, Baumann Michael, Beyreuther Elke, Bokor Jozef, Enghardt Wolfgang, Gantz Sebastian, Hejzlar Martin, Kurth Fritz, Meyer Markus, Pieck Stefan, Richter Christian, Pawelke Jörg

机构信息

Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

出版信息

Front Oncol. 2025 Jun 5;15:1594973. doi: 10.3389/fonc.2025.1594973. eCollection 2025.

DOI:10.3389/fonc.2025.1594973
PMID:40538840
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12176844/
Abstract

The proton therapy facility in Dresden, Germany, has one treatment room equipped with a rotating gantry where patients are treated and an experimental room equipped with two horizontal beamlines for translational research. The present work describes the technical characteristics and provides measured beam data of these two complementary beamlines, one delivering scanned beams with quasi-clinical parameters and the other one stationary continuous and pulsed pencil beams with parameters exceeding the clinically used range. Features of the facility are the large scale of the experimental room enabling the development and installation of large devices and the parallel beam operation with the clinical room allowing irradiation experiments on weekdays and during daytime. An overview of past and ongoing physics and biology experiments performed at the facility by internal and external researchers from academia and industry is given, demonstrating its versatile experimental capabilities. This includes the development of novel proton therapy approaches and technology as well as elaborate and small animal experiments for which the necessary infrastructure is available in the same building.

摘要

德国德累斯顿的质子治疗设施有一个配备旋转机架的治疗室用于治疗患者,还有一个配备两条水平束线的实验室用于转化研究。本工作描述了这两条互补束线的技术特性,并提供了测量的束流数据,一条束线提供具有准临床参数的扫描束,另一条提供参数超出临床使用范围的固定连续和脉冲笔形束。该设施的特点是实验室规模大,能够开发和安装大型设备,以及与临床室并行的束流运行,允许在工作日和白天进行辐照实验。概述了来自学术界和工业界的内部和外部研究人员在该设施进行的过去和正在进行的物理和生物学实验,展示了其多功能的实验能力。这包括新型质子治疗方法和技术的开发,以及在同一栋楼内具备必要基础设施的精细和小动物实验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/35d2f817afe1/fonc-15-1594973-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/02893364909f/fonc-15-1594973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/231548cd2a38/fonc-15-1594973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/b6e500e1edec/fonc-15-1594973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/640d0f48bbb1/fonc-15-1594973-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/35d2f817afe1/fonc-15-1594973-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/02893364909f/fonc-15-1594973-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/231548cd2a38/fonc-15-1594973-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/b6e500e1edec/fonc-15-1594973-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/640d0f48bbb1/fonc-15-1594973-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/35d2f817afe1/fonc-15-1594973-g005.jpg

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本文引用的文献

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Characterisation of the HollandPTC R&D proton beamline for physics and radiobiology studies.用于物理和放射生物学研究的荷兰质子治疗中心研发质子束线的特性描述。
Phys Med. 2025 Feb;130:104883. doi: 10.1016/j.ejmp.2024.104883. Epub 2025 Jan 7.
2
Design and dosimetric characterization of a transportable proton minibeam collimation system.一种可移动质子微束准直系统的设计与剂量学特性
Front Oncol. 2024 Dec 17;14:1473625. doi: 10.3389/fonc.2024.1473625. eCollection 2024.
3
Proton bunch monitors for the clinical translation of prompt gamma-ray timing.
用于即时伽马射线定时临床转化的质子束监视器。
Phys Med Biol. 2024 Nov 12;69(22). doi: 10.1088/1361-6560/ad8c96.
4
Organization and operation of multi particle therapy facilities: the Marburg Ion-Beam Therapy Center, Germany (MIT).多粒子治疗设施的组织与运营:德国马尔堡离子束治疗中心(MIT)
Health Technol (Berl). 2024;14(5):929-938. doi: 10.1007/s12553-024-00881-4. Epub 2024 May 21.
5
Absolute energy-dependent scintillating screen calibration for real-time detection of laser-accelerated proton bunches.用于激光加速质子束实时检测的绝对能量相关闪烁屏校准
Rev Sci Instrum. 2024 Jul 1;95(7). doi: 10.1063/5.0206931.
6
Simulation and experimental benchmarking of a proton pencil beam scanning nozzle model for development of MR-integrated proton therapy.质子笔形束扫描喷嘴模型的仿真与实验基准测试,用于开发与磁共振集成的质子治疗。
Med Phys. 2024 Sep;51(9):6196-6205. doi: 10.1002/mp.17279. Epub 2024 Jul 1.
7
-establishment of small animal proton and photon image-guided radiation experiments.建立小动物质子和光子图像引导放射实验。
Phys Med Biol. 2024 Apr 24;69(9). doi: 10.1088/1361-6560/ad3887.
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Dose and dose rate dependence of the tissue sparing effect at ultra-high dose rate studied for proton and electron beams using the zebrafish embryo model.使用斑马鱼胚胎模型研究超高剂量率下质子和电子束的组织保护效应的剂量和剂量率依赖性。
Radiother Oncol. 2024 May;194:110197. doi: 10.1016/j.radonc.2024.110197. Epub 2024 Mar 5.
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