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德累斯顿质子治疗设施的研究束流线:可用基础设施与实验能力。

The research beamlines at the Dresden proton therapy facility: available infrastructure and experimental capabilities.

作者信息

Horst Felix, Bodenstein Elisabeth, Baumann Michael, Beyreuther Elke, Bokor Jozef, Enghardt Wolfgang, Gantz Sebastian, Hejzlar Martin, Kurth Fritz, Meyer Markus, Pieck Stefan, Richter Christian, Pawelke Jörg

机构信息

Institute of Radiooncology - OncoRay, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden and Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

出版信息

Front Oncol. 2025 Jun 5;15:1594973. doi: 10.3389/fonc.2025.1594973. eCollection 2025.

Abstract

The proton therapy facility in Dresden, Germany, has one treatment room equipped with a rotating gantry where patients are treated and an experimental room equipped with two horizontal beamlines for translational research. The present work describes the technical characteristics and provides measured beam data of these two complementary beamlines, one delivering scanned beams with quasi-clinical parameters and the other one stationary continuous and pulsed pencil beams with parameters exceeding the clinically used range. Features of the facility are the large scale of the experimental room enabling the development and installation of large devices and the parallel beam operation with the clinical room allowing irradiation experiments on weekdays and during daytime. An overview of past and ongoing physics and biology experiments performed at the facility by internal and external researchers from academia and industry is given, demonstrating its versatile experimental capabilities. This includes the development of novel proton therapy approaches and technology as well as elaborate and small animal experiments for which the necessary infrastructure is available in the same building.

摘要

德国德累斯顿的质子治疗设施有一个配备旋转机架的治疗室用于治疗患者,还有一个配备两条水平束线的实验室用于转化研究。本工作描述了这两条互补束线的技术特性,并提供了测量的束流数据,一条束线提供具有准临床参数的扫描束,另一条提供参数超出临床使用范围的固定连续和脉冲笔形束。该设施的特点是实验室规模大,能够开发和安装大型设备,以及与临床室并行的束流运行,允许在工作日和白天进行辐照实验。概述了来自学术界和工业界的内部和外部研究人员在该设施进行的过去和正在进行的物理和生物学实验,展示了其多功能的实验能力。这包括新型质子治疗方法和技术的开发,以及在同一栋楼内具备必要基础设施的精细和小动物实验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/675b/12176844/02893364909f/fonc-15-1594973-g001.jpg

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