Bami Marzieh Sajadi, Khazaeli Payam, Lahiji Shayan Fakhraei, Dehghannoudeh Gholamreza, Banat Ibrahim M, Ohadi Mandana
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Department of Bioengineering, Biopharmaceutical Research Laboratory, Hanyang University, Seoul, South Korea.
AIMS Microbiol. 2024 Jul 30;10(3):596-607. doi: 10.3934/microbiol.2024028. eCollection 2024.
Microneedles, a novel transdermal delivery system, were designed to improve drug delivery and address the challenges typically encountered with traditional injection practices. Discovering new and safe excipients for microneedle coating to replace existing chemical surfactants is advantageous to minimize their side effect on viable tissues. However, some side effects have also been observed for this application. The vast majority of studies suggest that using synthetic surfactants in microneedle formulations may result in skin irritation among other adverse effects. Hence, increasing knowledge about these components and their potential impacts on skin paves the way for finding preventive strategies to improve their application safety and potential efficacy. Biosurfactants, which are naturally produced surface active microbial products, are proposed as an alternative to synthetic surfactants with reduced side effects. The current review sheds light on potential and regulatory aspects of biosurfactants as safe excipients in the coating of microneedles.
微针是一种新型的透皮给药系统，旨在改善药物递送并应对传统注射方法中常见的挑战。寻找用于微针涂层的新型安全辅料以替代现有的化学表面活性剂，有利于将其对活组织的副作用降至最低。然而，在该应用中也观察到了一些副作用。绝大多数研究表明，在微针制剂中使用合成表面活性剂可能会导致皮肤刺激等不良反应。因此，增加对这些成分及其对皮肤潜在影响的了解，为寻找预防策略以提高其应用安全性和潜在疗效铺平了道路。生物表面活性剂是天然产生的具有表面活性的微生物产物，被提议作为副作用较小的合成表面活性剂的替代品。本综述揭示了生物表面活性剂作为微针涂层中安全辅料的潜力和监管方面。
