Advantific, LLC, Princeton, NJ.
J Manag Care Spec Pharm. 2024 Oct;30(10-a Suppl):S1-S8. doi: 10.18553/jmcp.2024.30.10-a.s1.
infestation is the cause of more than two-thirds of all cases of blepharitis in the United States. Although symptoms may include crustiness, redness, or itching of the eyelids, diagnosis can be accomplished through a simple examination of the eyelashes. The presence of a waste product of the mite, known as collarettes, on the base of the eyelashes is a pathognomonic sign of blepharitis. infestation that results in blepharitis may cause blockage and ultimately atrophy of the meibomian glands, worsening dry eye disease. Until recently, management of blepharitis has been limited by a lack of approved therapy options. Lotilaner ophthalmic solution 0.25%, the first approved therapy for treatment of blepharitis, has not only been shown to eradicate mites in one-half to two-thirds of patients following short-term treatment but also demonstrated continued benefits through 1 year of follow-up. In addition to managing blepharitis, treatment with lotilaner ophthalmic solution 0.25% may aid in the management of dry eye disease and other forms of ocular surface disease caused by complications of infestation. As a result, it is possible that successful management of blepharitis may reduce chronic use of health care resources dedicated to managing other chronic ocular conditions. As eye care professionals recognize infestation as a key mediator of ocular surface disease, increasing diagnostic awareness and addressing this underlying cause of blepharitis may reduce the need for specialist follow-up care, decrease the need for chronic therapy, and improve patient outcomes. Through routine screening for infestation and blepharitis, eye care professionals can now address an underlying factor in ocular surface disease to improve use of health care resources in the community.
在美国,超过三分之二的睑缘炎病例是由寄生虫感染引起的。虽然症状可能包括眼睑结痂、发红或瘙痒,但通过简单的睫毛检查就可以做出诊断。在睫毛根部存在螨虫的代谢产物——collarettes,这是睑缘炎的特征性标志。寄生虫感染引起的睑缘炎可能导致睑板腺阻塞,最终萎缩,使干眼症恶化。直到最近,由于缺乏经过批准的治疗方案,睑缘炎的管理一直受到限制。Lotilaner 眼科溶液 0.25%是第一种被批准用于治疗睑缘炎的药物,不仅在短期治疗后有一半至三分之二的患者能够根除螨虫,而且在 1 年的随访中也显示出持续的益处。除了治疗睑缘炎外,用 Lotilaner 眼科溶液 0.25%治疗还可以帮助治疗因寄生虫感染并发症引起的干眼症和其他形式的眼表面疾病。因此,成功治疗睑缘炎可能会减少用于管理其他慢性眼部疾病的慢性保健资源的使用。由于眼保健专业人员认识到寄生虫感染是眼表面疾病的关键介导因素,因此增加对这种睑缘炎潜在病因的认识可能会减少对专科随访护理的需求,减少慢性治疗的需要,并改善患者的预后。通过对寄生虫感染和睑缘炎的常规筛查,眼保健专业人员现在可以解决眼表面疾病的潜在因素,从而改善社区内医疗资源的利用。