Department of Pathology, School of Basic Medical Sciences, Xinjiang Medical University, Ürümqi, 830017, Xinjiang, People's Republic of China.
Institute of Medical Sciences, Xinjiang Medical University, Xinjiang, China.
Sci Rep. 2024 Sep 2;14(1):19155. doi: 10.1038/s41598-024-63174-w.
Traditional chemotherapy drugs for cervical cancer often cause significant toxic side effects and drug resistance problems, highlighting the urgent need for more innovative and effective treatment strategies. Magnesium alloy is known to be degradable and biocompatible. The release of degradation products Mg, OH, and H from magnesium alloy can alter the tumor microenvironment, providing potential anti-tumor properties. We explored the innovative use of magnesium alloy biomaterials in the treatment of cervical cancer, investigating how various concentrations of Mg on the proliferation and cell death of cervical cancer cells. The results revealed that varying concentrations of Mg significantly inhibited cervical cancer by arresting the cell cycle in the G0/G1 phase and inducing apoptosis in SiHa cells, effectively reducing tumor cell proliferation. In vivo experiments demonstrated that 20 mM Mg group had the smallest tumor volume, exhibiting a potent inhibitory effect on the biological characteristics of cervical cancer. This enhances the therapeutic potential of this biomaterial as a local anti-tumor therapy and lays a theoretical foundation for the potential application of magnesium in the treatment of cervical cancer.
传统的宫颈癌化疗药物常引起显著的毒副作用和耐药问题，凸显出更具创新性和有效性的治疗策略的迫切需求。镁合金具有可降解性和生物相容性。镁合金降解产物 Mg、OH 和 H 的释放可改变肿瘤微环境，提供潜在的抗肿瘤特性。我们探索了镁合金生物材料在宫颈癌治疗中的创新应用，研究了不同浓度的 Mg 对宫颈癌细胞增殖和细胞死亡的影响。结果表明，不同浓度的 Mg 通过将细胞周期阻滞在 G0/G1 期并诱导 SiHa 细胞凋亡，显著抑制宫颈癌，有效减少肿瘤细胞增殖。体内实验表明，20 mM Mg 组的肿瘤体积最小，对宫颈癌的生物学特性具有强大的抑制作用。这增强了该生物材料作为局部抗肿瘤治疗的潜力，并为镁在宫颈癌治疗中的潜在应用奠定了理论基础。
