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Is it time to rethink the relationship between adipose inflammation and insulin resistance?

作者信息

Rosen Evan D, Kajimura Shingo

机构信息

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Harvard Medical School, Boston, Massachusetts, USA.

出版信息

J Clin Invest. 2024 Sep 3;134(17):e184663. doi: 10.1172/JCI184663.

DOI:10.1172/JCI184663
PMID:39225103
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11364379/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7537/11364379/2ebdc760b4fb/jci-134-184663-g249.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7537/11364379/2ebdc760b4fb/jci-134-184663-g249.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7537/11364379/2ebdc760b4fb/jci-134-184663-g249.jpg

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本文引用的文献

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Recent advances in the effect of adipose tissue inflammation on insulin resistance.脂肪组织炎症对胰岛素抵抗影响的最新进展。
Cell Signal. 2024 Aug;120:111229. doi: 10.1016/j.cellsig.2024.111229. Epub 2024 May 17.
2
Macrophage function in adipose tissue homeostasis and metabolic inflammation.脂肪组织稳态和代谢性炎症中的巨噬细胞功能。
Nat Immunol. 2023 May;24(5):757-766. doi: 10.1038/s41590-023-01479-0. Epub 2023 Apr 3.
3
High-throughput genetic clustering of type 2 diabetes loci reveals heterogeneous mechanistic pathways of metabolic disease.
Oxidative stress markers and inflammation in type 1 and 2 diabetes are affected by BMI, treatment type, and complications.
1型和2型糖尿病中的氧化应激标志物及炎症受体重指数、治疗类型和并发症的影响。
Sci Rep. 2025 Jul 2;15(1):23605. doi: 10.1038/s41598-025-05818-z.
4
The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity.微小RNA miR-30a可阻止肥胖症中脂肪组织纤维化的积累。
J Clin Invest. 2025 Jun 5;135(15). doi: 10.1172/JCI175566. eCollection 2025 Aug 1.
高通量遗传聚类分析 2 型糖尿病相关位点揭示代谢性疾病的不同机制途径。
Diabetologia. 2023 Mar;66(3):495-507. doi: 10.1007/s00125-022-05848-6. Epub 2022 Dec 20.
4
Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice.多组学揭示了肥胖相关免疫细胞表型在小鼠减肥和体重反弹过程中在脂肪组织中的持续存在。
Nat Commun. 2022 May 26;13(1):2950. doi: 10.1038/s41467-022-30646-4.
5
Adipose Tissue Inflammation Is Not Related to Adipose Insulin Resistance in Humans.脂肪组织炎症与人类脂肪胰岛素抵抗无关。
Diabetes. 2022 Mar 1;71(3):381-393. doi: 10.2337/db21-0609.
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Diabetes. 2020 Oct;69(10):2086-2093. doi: 10.2337/dbi20-0001. Epub 2020 Aug 25.
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Metabolic Inflammation and Insulin Resistance in Obesity.肥胖相关的代谢炎症与胰岛素抵抗
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