Jones B A, Agthe P, Scarpante E, Crawford A, Black V, Espadas I, Formoso S, Fraser A R
Anderson Moores Veterinary Specialists, part of Linnaeus Veterinary Limited, Winchester, UK.
Willows Veterinary Centre and Referral Service, part of Linnaeus Veterinary Limited, Solihull, UK.
J Small Anim Pract. 2025 Jan;66(1):33-42. doi: 10.1111/jsap.13775. Epub 2024 Sep 4.
To describe the MRI findings in a UK referral population of dogs with steroid-responsive meningitis-arteritis and to determine if they were associated with any specific clinical features or outcomes.
We performed a multi-centre retrospective case series of dogs diagnosed with steroid-responsive meningitis-arteritis in the UK that underwent MRI. Blinded consensus review of the MRI studies was performed and the findings described. The presence or absence of specific MRI abnormalities were analysed for significant associations with presenting signs, results of investigations or case outcomes.
Fifty-three dogs were included. The most common MRI findings were paravertebral muscle changes (30/53; 56.6%), meningeal contrast enhancement (13/41; 31.7%) and spinal cord parenchymal T2-W hyperintensity (15/53; 28.3%). Haemorrhage was observed in five of 53 (9.4%) cases - three intradural-extramedullary, one intramedullary and one extradural. Following binary logistic regressions, T2-W spinal cord parenchymal hyperintensity had a significant positive association with paresis/paralysis (odds ratio 14.86, 95% confidence interval 1.42 to 154.99) as did haemorrhage (odds ratio 16.12, confidence interval 2.05 to 126.73). Fifty-two (98.1%) dogs survived to discharge. Relapse occurred in nine of 29 (31.0%) dogs with sufficient follow-up, and no MRI finding had a significant relationship with its occurrence.
Magnetic resonance imaging findings for steroid-responsive meningitis-arteritis can be severe and extensive, as can the clinical presentation. The presence of paresis/paralysis should raise concern for haemorrhage, though most dogs still have a good prognosis.
描述英国转诊的患有类固醇反应性脑膜炎-动脉炎的犬类的MRI表现，并确定这些表现是否与任何特定的临床特征或预后相关。
我们对英国诊断为类固醇反应性脑膜炎-动脉炎并接受MRI检查的犬类进行了多中心回顾性病例系列研究。对MRI研究进行了盲法一致性审查并描述了结果。分析特定MRI异常的有无与就诊体征、检查结果或病例预后之间的显著相关性。
共纳入53只犬。最常见的MRI表现为椎旁肌肉改变（30/53；56.6%）、脑膜对比增强（13/41；31.7%）和脊髓实质T2加权高信号（15/53；28.3%）。53例中有5例（9.4%）观察到出血——3例硬膜内髓外出血、1例髓内出血和1例硬膜外出血。经过二元逻辑回归分析，脊髓实质T2加权高信号与轻瘫/瘫痪有显著正相关（比值比14.86，95%置信区间1.42至154.99），出血情况也是如此（比值比16.12，置信区间2.05至126.73）。52只（98.1%）犬存活至出院。在有足够随访的29只犬中有9只（31.0%）复发，且没有MRI表现与其复发有显著关系。
类固醇反应性脑膜炎-动脉炎的磁共振成像表现可能很严重且广泛，临床表现也是如此。轻瘫/瘫痪的出现应引起对出血的关注，不过大多数犬的预后仍然良好。
