Lin Shanshan, Yang Yuanjian, Zhou Zhou, Li Wen, Wang Xianliang, Liu Yu, Bi Yingfei, Mao Jingyuan
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Front Pharmacol. 2024 Aug 20;15:1399850. doi: 10.3389/fphar.2024.1399850. eCollection 2024.
The heart is a multicellular system, and the intercellular crosstalk mechanism is very important for the growth and development of the heart and even the organs, tissues, and cells at a distance. As a kind of extracellular vesicle, exosomes are released by different types of cells and can carry specific genetic material, endosomal proteins, cytokines, etc., which are the main material basis for mediating cell crosstalk mechanism. Among them, microRNA carried by cardiac cells-derived exosomes have highly conserved sequences and play a key role in regulating the function of organs, tissues, and cells related to cardiovascular diseases and their complications and comorbidities, which have attracted extensive attention in the medical community in recent years. Following up on the latest research progress at home and abroad, this review systematically summarized the regulatory role of microRNA from cardiac cells-derived exosomes in various cell crosstalk, including not only cardiac cells (including cardiomyocytes, fibroblasts, myofibroblast, cardiac progenitor cells, cardiac microvascular endothelial cells, cardiosphere-derived cells, etc.) but also tumor cells, bone marrow progenitor cells, and other tissue cells, in order to provide a reference for the prevention and treatment of cardiovascular diseases and their complications and comorbidities.
心脏是一个多细胞系统，细胞间的相互作用机制对于心脏乃至远处的器官、组织和细胞的生长发育都非常重要。作为一种细胞外囊泡，外泌体由不同类型的细胞释放，可携带特定的遗传物质、内体蛋白、细胞因子等，是介导细胞间相互作用机制的主要物质基础。其中，心脏细胞来源的外泌体携带的微小RNA具有高度保守的序列，在调节与心血管疾病及其并发症和合并症相关的器官、组织和细胞功能方面发挥着关键作用，近年来在医学界引起了广泛关注。本文追踪国内外最新研究进展，系统总结了心脏细胞来源的外泌体中微小RNA在各种细胞间相互作用中的调节作用，这些细胞不仅包括心脏细胞（包括心肌细胞、成纤维细胞、肌成纤维细胞、心脏祖细胞、心脏微血管内皮细胞、心脏球衍生细胞等），还包括肿瘤细胞、骨髓祖细胞和其他组织细胞，以期为心血管疾病及其并发症和合并症的防治提供参考。
