Ravikumar Rajathadri H, Pegu Baby, Bansal Himanti, Soni Kapil Dev
Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, Delhi, India.
J Family Med Prim Care. 2024 Aug;13(8):3431-3434. doi: 10.4103/jfmpc.jfmpc_1850_23. Epub 2024 Jul 26.
Digoxin, a cardiac glycoside, functions by inhibiting the sodium potassium ATPase pump. It's crucial to note that digoxin has a very narrow therapeutic range. Its serum level vary due to changes in body weight, age, renal function, hepatic impairment and concomitant drug therapy. Chronic toxicity can lead to different types of arrrythmia,which span from heart blocks to ventricular tachycardia. This report present a case of an elderly male, where Digoxin toxicity resulted in syncope and mild traumatic brain injury. Initially upon patient's presentation ECG indicated myocardial infarction, subsequently bradycardia and complete heart block. The patient had a known history of chronic kidney disease and was prescribed 0.25mg of digoxin regularly without dose adjustment, which might have resulted in reduced digoxin elimination, leading to toxicity. Thus this case demonstrates a classic presentation of digoxin toxicity. Multiple risk factor such as old age, impaired renal function with continued digoxin treatment without dose adjustment was likely the cause of toxicity.
地高辛,一种强心苷,通过抑制钠钾ATP酶泵发挥作用。需要注意的是,地高辛的治疗范围非常窄。其血清水平会因体重、年龄、肾功能、肝功能损害及联合药物治疗的变化而有所不同。慢性毒性可导致不同类型的心律失常,从心脏传导阻滞到室性心动过速。本报告介绍了一例老年男性病例,地高辛中毒导致晕厥和轻度创伤性脑损伤。患者初诊时心电图显示心肌梗死,随后出现心动过缓和完全性心脏传导阻滞。该患者有慢性肾病病史,常规服用0.25mg地高辛且未调整剂量,这可能导致地高辛清除减少,从而引发中毒。因此,该病例展示了地高辛中毒的典型表现。多种风险因素,如老年、肾功能受损且持续使用地高辛治疗而未调整剂量,可能是中毒的原因。