Billey Alvin, Saleem Asra, Zeeshan Bushra, Dissanayake Gayanthi, Zergaw Meaza F, Elgendy Mohamed, Nassar Sondos T
Internal Medicine and Gastroenterology, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Cureus. 2024 Aug 3;16(8):e66098. doi: 10.7759/cureus.66098. eCollection 2024 Aug.
Functional dyspepsia (FD) is a prevalent chronic digestive disorder that significantly impacts patients' quality of life. Sleep disturbance (SD) is common among FD patients, yet the relationship between SD and FD remains poorly characterized. This systematic review explores the bidirectional relationship between FD and SD, investigating underlying mechanisms and implications for management. A rigorous and comprehensive systematic search was conducted across PubMed, PubMed Central (PMC), Google Scholar, Cochrane Library, and ScienceDirect using select keywords related to SD and FD. Only studies published in English from the past 10 years that met inclusion and exclusion criteria were included. Quality assessment tools specific to study types were employed to minimize bias. After applying inclusion and exclusion criteria and quality assessments, the review encompassed 30 studies. The key findings reveal that FD is frequently associated with SD, with a significant proportion of FD patients reporting poor sleep quality. The mechanisms linking SD and FD are complex, involving the circadian rhythm, visceral hypersensitivity, immune responses, and psychological factors. Nonpharmacological treatments like cognitive behavioral therapy (CBT), acupuncture, and pharmacological neuromodulators have shown promise in managing FD and SD, offering hope for improved patient outcomes. SD and FD share a significant bidirectional relationship, influenced by a complex interplay of physiological, psychological, and lifestyle factors. Addressing SD in FD patients may improve overall symptom management. Further research is crucial, as it should focus on isolating specific SD causes and their direct impacts on FD and other functional gastrointestinal disorders (FGIDs), opening up new avenues for understanding and treatment.
功能性消化不良（FD）是一种常见的慢性消化系统疾病，严重影响患者的生活质量。睡眠障碍（SD）在FD患者中很常见，但SD与FD之间的关系仍未得到充分描述。本系统综述探讨了FD与SD之间的双向关系，研究其潜在机制及对管理的影响。使用与SD和FD相关的特定关键词，在PubMed、PubMed Central（PMC）、谷歌学术、Cochrane图书馆和ScienceDirect上进行了严格而全面的系统检索。仅纳入过去10年以英文发表且符合纳入和排除标准的研究。采用针对研究类型的质量评估工具以尽量减少偏倚。在应用纳入和排除标准及质量评估后，该综述涵盖了30项研究。主要研究结果表明，FD常与SD相关，相当一部分FD患者报告睡眠质量差。连接SD和FD的机制很复杂，涉及昼夜节律、内脏超敏反应、免疫反应和心理因素。认知行为疗法（CBT）、针灸等非药物治疗以及药物神经调节剂在管理FD和SD方面已显示出前景，为改善患者预后带来了希望。SD和FD存在显著的双向关系，受生理、心理和生活方式因素的复杂相互作用影响。解决FD患者的SD问题可能会改善整体症状管理。进一步的研究至关重要，因为应专注于确定特定的SD病因及其对FD和其他功能性胃肠疾病（FGID）的直接影响，为理解和治疗开辟新途径。
