Accuracy and technical characteristics of CYP2C19 point of care tests: a systematic review.

To assess the accuracy and technical characteristics of point of care tests (POCTs). Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting loss of function (LOF) alleles. Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive). The POCTs had very high sensitivity and specificity for the alleles they tested for. Twenty-two studies reported technical characteristics: POCTs were easy to operate and provided results quickly. Limited data were reported for test failure rate and cost. POCTs may be a useful alternative to laboratory-based testing to guide antiplatelet therapy. Further data are required on accuracy (GMEX; Genedrive), test failure and cost (all POCT).