Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
South West NHS Genomic Medicine Service Alliance.
Pharmacogenomics. 2024;25(8-9):407-423. doi: 10.1080/14622416.2024.2392479. Epub 2024 Sep 4.
To assess the accuracy and technical characteristics of point of care tests (POCTs). Systematic review of primary studies, in any population or setting, that evaluated POCTs for detecting loss of function (LOF) alleles. Eleven studies provided accuracy data (eight Spartan; one Genomadix Cube; one GMEX; one Genedrive). The POCTs had very high sensitivity and specificity for the alleles they tested for. Twenty-two studies reported technical characteristics: POCTs were easy to operate and provided results quickly. Limited data were reported for test failure rate and cost. POCTs may be a useful alternative to laboratory-based testing to guide antiplatelet therapy. Further data are required on accuracy (GMEX; Genedrive), test failure and cost (all POCT).
评估即时检测（POCT）的准确性和技术特点。对在任何人群或环境中评估用于检测功能丧失（LOF）等位基因的 POCT 的原始研究进行系统评价。11 项研究提供了准确性数据（8 项 Spartan；1 项 Genomadix Cube；1 项 GMEX；1 项 Genedrive）。POCT 对其所检测的等位基因具有非常高的灵敏度和特异性。22 项研究报告了技术特点：POCT 易于操作，并且能够快速提供结果。仅报告了有限的数据用于检测失败率和成本。POCT 可能是实验室检测的有用替代方法，可用于指导抗血小板治疗。需要进一步的准确性数据（GMEX；Genedrive）、检测失败和成本数据（所有 POCT）。
