School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China.
Department of Chemistry, Changzhi University, Changzhi 046011, China.
ACS Appl Mater Interfaces. 2024 Sep 18;16(37):49124-49134. doi: 10.1021/acsami.4c10334. Epub 2024 Sep 4.
Photocatalytic molecules are considered to be one of the most promising substitutions of antibiotics against multidrug-resistant bacterial infections. However, the strong excitonic effect greatly restricts their efficiency in antibacterial performance. Inspired by the interfacial dipole effect, a TiC MXene modified photocatalytic molecule (MTTTPyB) is designed and synthesized to enhance the yield of photogenerated carriers under light irradiation. The alignment of the energy level between TiC and MTTTPyB results in the formation of an interfacial dipole, which can provide an impetus for the separation of carriers. Under the role of a dipole electric field, these photogenerated electrons can rapidly migrate to the side of TiC for improving the separation efficiency of photogenerated electrons and holes. Thus, more electrons can be utilized to produce reactive oxygen species (ROS) under light irradiation. As a result, over 97.04% killing efficiency can be reached for () when the concentration of MTTTPyB/TiC was 50 ppm under 660 nm irradiation for 15 min. A microneedle (MN) patch made from MTTTPyB/TiC was used to treat the subcutaneous bacterial infection. This design of an organic-inorganic interface provides an effective method to minimize the excitonic effect of molecules, further expanding the platform of inorganic/organic hybrid materials for efficient phototherapy.
光催化分子被认为是替代抗生素治疗多药耐药菌感染最有前途的方法之一。然而，强烈的激子效应对其抗菌性能的效率有很大的限制。受界面偶极子效应的启发，设计并合成了一种 TiC MXene 修饰的光催化分子（MTTTPyB），以增强光照射下光生载流子的产率。TiC 和 MTTTPyB 之间的能级排列导致形成界面偶极子，这可为载流子的分离提供动力。在偶极电场的作用下，这些光生电子可以快速迁移到 TiC 的一侧，从而提高光生电子和空穴的分离效率。因此，在 660nm 光照 15min 下，当浓度为 50ppm 的 MTTTPyB/TiC 时，对于 ()，可以达到超过 97.04%的杀伤效率。用 MTTTPyB/TiC 制成的微针 (MN) 贴片用于治疗皮下细菌感染。这种有机-无机界面的设计为最小化分子的激子效应提供了一种有效的方法，进一步扩展了无机/有机杂化材料用于高效光疗的平台。
