Höchsmann Christoph, Dorling James L, Lavie Carl J, Katzmarzyk Peter T
Department of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, 80809, Munich, Germany.
Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Curr Cardiol Rep. 2024 Nov;26(11):1321-1327. doi: 10.1007/s11886-024-02130-6. Epub 2024 Sep 4.
Considerable current interest is directed at pharmacological agents for producing significant weight loss. However, healthy lifestyle choices can also lead to clinically meaningful weight loss and improvements in cardiovascular disease (CVD) risk factors.
In this review, we summarize the recent research from our PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) randomized controlled trial and review previous data on the potential benefits of cardiac rehabilitation and exercise training (CRET) programs to produce weight loss and improvements in CVD risk factors. Although obesity medications are becoming extremely attractive for secondary and even primary CVD prevention, high-intensity non-pharmacological therapies with healthy lifestyle choices reviewed herein can also lead to substantial health improvements in patients with obesity, including improvements in body weight and other body composition parameters as well as overall CVD risk.
目前人们对能显著减轻体重的药物制剂有着浓厚兴趣。然而，健康的生活方式选择也能带来具有临床意义的体重减轻，并改善心血管疾病（CVD）风险因素。
在本综述中，我们总结了来自路易斯安那州初级保健促进成功减肥（PROPEL）随机对照试验的最新研究，并回顾了以往关于心脏康复和运动训练（CRET）计划在减轻体重及改善CVD风险因素方面潜在益处的数据。尽管肥胖药物在二级甚至一级CVD预防中变得极具吸引力，但本文所综述的包含健康生活方式选择的高强度非药物疗法，也能使肥胖患者的健康状况得到显著改善，包括体重和其他身体成分参数的改善以及整体CVD风险的降低。
