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乌干达西南部感染艾滋病毒的青少年和青年中艾滋病毒治疗依从性自我效能的相关因素。

Correlates of HIV treatment adherence self-efficacy among adolescents and young adults living with HIV in southwestern Uganda.

作者信息

Ashaba Scholastic, Baguma Charles, Tushemereirwe Patricia, Nansera Denis, Maling Samuel, Zanon Brian C, Tsai Alexander C

机构信息

Department of Psychiatry, Mbarara University of Science and Technology, Mbarara, Uganda.

Global Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.

出版信息

PLOS Glob Public Health. 2024 Sep 4;4(9):e0003600. doi: 10.1371/journal.pgph.0003600. eCollection 2024.

DOI:10.1371/journal.pgph.0003600
PMID:39231105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11373852/
Abstract

Adherence to antiretroviral therapy (ART) among adolescents and young adults living with HIV (AYLHIV) in sub-Saharan Africa is sub-optimal compared to younger children and older adults. Adherence self-efficacy is one of the intrapersonal factors most strongly correlated with ART adherence. The role of adherence self-efficacy in ART adherence among AYLHIV is not well studied in Uganda. We enrolled 300 AYLHIV between October and December 2021 from an HIV clinic in southwestern Uganda. We collected information on adherence self-efficacy, HIV stigma, depression, self-management, and social skills. We used linear regression to estimate the association between adherence self-efficacy and the covariates of interest. At multivariable adjustment self-management (b = 0.29, 95% CI 0.23-0.35, p<0.001) and social skills (b = 0.16, 95% CI 0.08-0.24; p<0.001) were statistically significantly associated with adherence self-efficacy. The findings imply that interventions directed at enhancing self-management and social skills in AYLHIV may increase adherence self-efficacy and, potentially, HIV outcomes among AYLHIV.

摘要

与年幼儿童和老年人相比，撒哈拉以南非洲地区感染艾滋病毒的青少年和青年（AYLHIV）对抗逆转录病毒疗法（ART）的依从性欠佳。依从性自我效能感是与ART依从性关联最为紧密的个人因素之一。在乌干达，AYLHIV中依从性自我效能感在ART依从性方面所起的作用尚未得到充分研究。2021年10月至12月期间，我们从乌干达西南部的一家艾滋病毒诊所招募了300名AYLHIV。我们收集了关于依从性自我效能感、艾滋病毒污名化、抑郁、自我管理和社交技能的信息。我们使用线性回归来估计依从性自我效能感与感兴趣的协变量之间的关联。在多变量调整中，自我管理（b = 0.29，95% CI 0.23 - 0.35，p<0.001）和社交技能（b = 0.16，95% CI 0.08 - 0.24；p<0.001）与依从性自我效能感在统计学上显著相关。研究结果表明，针对提高AYLHIV自我管理和社交技能的干预措施可能会提高依从性自我效能感，并有可能改善AYLHIV的艾滋病毒相关结局。

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Correlates of HIV treatment adherence self-efficacy among adolescents and young adults living with HIV in southwestern Uganda.

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引用本文的文献

[1]
Medication literacy and treatment adherence in people living with human immunodeficiency virus: Mediating effects of psychosocial factors.

World J Psychiatry. 2025-8-19

[2]
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[3]
Correction: Correlates of HIV treatment adherence self-efficacy among adolescents and young adults living with HIV in southwestern Uganda.

PLOS Glob Public Health. 2024-10-15

本文引用的文献

[1]
A Structural Equation Model of the Impact of a Family-Based Economic Intervention on Antiretroviral Therapy Adherence Among Adolescents Living With HIV in Uganda.

J Adolesc Health. 2023-5

[2]
Intrapersonal predictors of internalized stigma among school going adolescents living with HIV in southwestern Uganda.

Psychol Health Med. 2023

[3]
Adolescent support club attendance and self-efficacy associated with HIV treatment outcomes in Tanzania.

PLOS Glob Public Health. 2022-10-3

[4]
Contextual Factors Influencing Self-Management of Adolescents and Youth Living with HIV: A Cross-Sectional Survey in Lesotho.

Int J Environ Res Public Health. 2022-12-23

[5]
The Role of Self-Efficacy in HIV treatment Adherence and its interaction with psychosocial factors among HIV Positive Adolescents in Transition to Adult Care in Kenya.

Vulnerable Child Youth Stud. 2022

[6]
Developing an app-based self-management program for people living with HIV: a randomized controlled pilot study during the COVID-19 pandemic.

Sci Rep. 2022-11-12

[7]
Challenges and Fears of Adolescents and Young Adults Living with HIV Facing Transition to Adult HIV Care.

AIDS Behav. 2023-4

[8]
Perspectives About Transition Readiness Among Adolescents and Young People Living With Perinatally Acquired HIV in Rural, Southwestern Uganda: A Qualitative Study.

J Assoc Nurses AIDS Care.

[9]
Self-efficacy for self-management and its influencing factors among adults living with HIV on antiretroviral therapy in northwest Ethiopia.

AIDS Care. 2022-12

[10]
Self-management interventions for adolescents living with HIV: a systematic review.

BMC Infect Dis. 2021-5-7

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