Ashaba Scholastic, Baguma Charles, Tushemereirwe Patricia, Nansera Denis, Maling Samuel, Zanon Brian C, Tsai Alexander C
Department of Psychiatry, Mbarara University of Science and Technology, Mbarara, Uganda.
Global Health Collaborative, Mbarara University of Science and Technology, Mbarara, Uganda.
PLOS Glob Public Health. 2024 Sep 4;4(9):e0003600. doi: 10.1371/journal.pgph.0003600. eCollection 2024.
Adherence to antiretroviral therapy (ART) among adolescents and young adults living with HIV (AYLHIV) in sub-Saharan Africa is sub-optimal compared to younger children and older adults. Adherence self-efficacy is one of the intrapersonal factors most strongly correlated with ART adherence. The role of adherence self-efficacy in ART adherence among AYLHIV is not well studied in Uganda. We enrolled 300 AYLHIV between October and December 2021 from an HIV clinic in southwestern Uganda. We collected information on adherence self-efficacy, HIV stigma, depression, self-management, and social skills. We used linear regression to estimate the association between adherence self-efficacy and the covariates of interest. At multivariable adjustment self-management (b = 0.29, 95% CI 0.23-0.35, p<0.001) and social skills (b = 0.16, 95% CI 0.08-0.24; p<0.001) were statistically significantly associated with adherence self-efficacy. The findings imply that interventions directed at enhancing self-management and social skills in AYLHIV may increase adherence self-efficacy and, potentially, HIV outcomes among AYLHIV.
与年幼儿童和老年人相比，撒哈拉以南非洲地区感染艾滋病毒的青少年和青年（AYLHIV）对抗逆转录病毒疗法（ART）的依从性欠佳。依从性自我效能感是与ART依从性关联最为紧密的个人因素之一。在乌干达，AYLHIV中依从性自我效能感在ART依从性方面所起的作用尚未得到充分研究。2021年10月至12月期间，我们从乌干达西南部的一家艾滋病毒诊所招募了300名AYLHIV。我们收集了关于依从性自我效能感、艾滋病毒污名化、抑郁、自我管理和社交技能的信息。我们使用线性回归来估计依从性自我效能感与感兴趣的协变量之间的关联。在多变量调整中，自我管理（b = 0.29，95% CI 0.23 - 0.35，p<0.001）和社交技能（b = 0.16，95% CI 0.08 - 0.24；p<0.001）与依从性自我效能感在统计学上显著相关。研究结果表明，针对提高AYLHIV自我管理和社交技能的干预措施可能会提高依从性自我效能感，并有可能改善AYLHIV的艾滋病毒相关结局。
