Neuendorff Nina Rosa, Wirth Rainer, Deschler-Baier Barbara
Klinik für Altersmedizin und Frührehabilitation, Marien Hospital Herne, Klinikum der Ruhr-Universität Bochum, Hölkeskampring 40, 44625, Herne, Deutschland.
Comprehensive Cancer Center, Universitätsklinik Würzburg, Würzburg, Deutschland.
Inn Med (Heidelb). 2025 Sep 5. doi: 10.1007/s00108-025-01978-2.
Frailty is a common geriatric syndrome in older patients with cancer. It affects prognosis and treatment tolerance in various ways. Frailty and cancer share several common risk factors, which are reflected in the hallmarks of aging. An oncogeriatric assessment with management (GAME) provides the opportunity to detect frailty and its related geriatric impairments and offers the possibility to compensate for frailty-associated vulnerability. Thus, higher-grade treatment-associated toxicities of the provided oncological treatments are reduced. Furthermore, treatment completion rates and quality of life can be improved by GAME. The following review article provides an overview of the general definition of physical and social frailty, its significance in oncology, and the evidence for GAME. Lastly, first study results of frailty-adapted treatment approaches are summarized.
衰弱是老年癌症患者中常见的老年综合征。它以多种方式影响预后和治疗耐受性。衰弱和癌症有几个共同的风险因素，这在衰老的特征中有所体现。老年肿瘤学评估与管理（GAME）提供了检测衰弱及其相关老年损伤的机会，并提供了弥补与衰弱相关的脆弱性的可能性。因此，所提供的肿瘤治疗中与较高等级治疗相关的毒性得以降低。此外，GAME可以提高治疗完成率和生活质量。以下综述文章概述了身体和社会衰弱的一般定义、其在肿瘤学中的意义以及GAME的证据。最后，总结了衰弱适应性治疗方法的首批研究结果。
