Hasanain Afnan, Almutawa Abdulmonem, Aljuaid Fahad, Tayeb Ahmad M, Bahattab Jumanah A, Assaedi Luai, Alshareef Khalid
Department of Dermatology, King Faisal Specialist Hospital & Research Centre, Jeddah, SAU.
Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Jeddah, SAU.
Cureus. 2024 Aug 5;16(8):e66191. doi: 10.7759/cureus.66191. eCollection 2024 Aug.
Bowen's disease (BD) is an in situ squamous cell carcinoma of the epidermis with multiple etiologies and a high incidence among Caucasians. It commonly occurs in photo-exposed areas of the skin, although other sites can also be affected. Most lesions are solitary, and their morphology can vary based on the lesion's age, origin, and degree of keratinization. A 50-year-old female from Saudi Arabia presented to the dermatology clinic with a three-year history of slowly enlarging skin lesions on the left side of her chest. Initially, the lesion appeared three years ago, but she observed changes and a darkening in color over the past year, accompanied by mild pain and itching. On examination, the lesion was a 2 × 2 cm, well-defined, unevenly pigmented brown-black plaque with a dispersed pigment pattern and irregular borders with globularity on the left side of the upper chest. A 4 mm punch biopsy was taken from the most pigmented area and sent for histopathological examination, which confirmed the diagnosis of pigmented BD.
鲍温病（BD）是一种表皮原位鳞状细胞癌，病因多样，在白种人中发病率较高。它通常发生于皮肤的光照暴露部位，不过其他部位也可能受累。多数损害为单发，其形态可因损害的年龄、起源及角化程度而有所不同。一名来自沙特阿拉伯的50岁女性前往皮肤科诊所就诊，其左侧胸部皮肤损害缓慢增大已有三年病史。最初，损害于三年前出现，但在过去一年里她观察到其有变化且颜色变深，伴有轻度疼痛和瘙痒。检查时，该损害为一个2×2厘米、边界清晰、色素沉着不均匀的棕黑色斑块，色素呈散在分布，上胸部左侧边界不规则且有球状隆起。从色素沉着最明显的区域取了一块4毫米的钻孔活检组织送去做组织病理学检查，结果确诊为色素性鲍温病。
