长链非编码RNA过表达与胃腺癌患者预后不良相关
Overexpression of Long Non-coding RNAs and Predict Poor Prognosis in Patients with Gastric Adenocarcinoma.
作者信息
Bagheri Mahdi, Aghaabdollahian Safieh, Asghardoust Rezaei Milad, Gholian Kholerdi Ali Mehdi, Raei Mehdi, Keyvanloo Shahrestanaki Mohammad
机构信息
Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Faculty of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran.
出版信息
Adv Biomed Res. 2024 Apr 27;13:34. doi: 10.4103/abr.abr_308_23. eCollection 2024.
BACKGROUND
LINC00092 and MCM3AP-AS1 long non-coding RNAs (LncRNAs) play significant roles in the development and pathogenesis of many cancers. However, their expression levels and prognostic values were not evaluated in human gastric adenocarcinoma (GAC). Therefore, the present study aimed to investigate the clinico-pathological correlations of LINC00092 and MCM3AP-AS1, LncRNAs expression in GAC, and evaluate their prognostic values.
MATERIALS AND METHODS
The expression of LINC00092 and MCM3AP-AS1 was detected in 89 GAC tissues by quantitative real-time reverse-transcription PCR (qRT-PCR).
RESULTS
Our results showed that LINC00092 and MCM3AP-AS1 are overexpressed in GAC patients and positively correlated with GAC invasion and vascular, peritoneal, and lymph node metastasis ( < 0.05). Furthermore, the results indicated that MCM3AP-AS1 ( = 0.0225) and LINC00092 ( < 0.001) have positive correlations with GAC patients' overall survival.
CONCLUSION
Altogether, the present results indicated that LINC00092 and MCM3AP-AS1 overexpression is associated with clinico-pathological characteristic of GAC patients. In addition, both of these LncRNAs may have prognostic value for estimation of patients' overall survival.
背景
长链非编码RNA（LncRNA）LINC00092和MCM3AP-AS1在多种癌症的发生发展及发病机制中发挥重要作用。然而，它们在人胃腺癌（GAC）中的表达水平及预后价值尚未得到评估。因此，本研究旨在探讨LINC00092和MCM3AP-AS1在GAC中的临床病理相关性、LncRNA表达情况，并评估它们的预后价值。
材料与方法
采用定量实时逆转录PCR（qRT-PCR）检测89例GAC组织中LINC00092和MCM3AP-AS1的表达。
结果
我们的结果显示，LINC00092和MCM3AP-AS1在GAC患者中过表达，且与GAC的侵袭以及血管、腹膜和淋巴结转移呈正相关（P<0.05）。此外，结果表明MCM3AP-AS1（P = 0.0225）和LINC00092（P<0.001）与GAC患者的总生存期呈正相关。
结论
总体而言，目前的结果表明LINC00092和MCM3AP-AS1的过表达与GAC患者的临床病理特征相关。此外，这两种LncRNA可能对评估患者的总生存期具有预后价值。
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