弥漫型胃癌的流行病学之谜。
The diffuse-type gastric cancer epidemiology enigma.
机构信息
Núcleo de Pesquisas em Oncologia, Universidade Federal do Pará, Belém, Pará, Brazil.
Serviço de Cirurgia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, Pará, Brazil.
出版信息
BMC Gastroenterol. 2020 Jul 13;20(1):223. doi: 10.1186/s12876-020-01354-4.
BACKGROUND
Intestinal and diffuse gastric adenocarcinomas differ in clinical, epidemiological and molecular features. However, most of the concepts related to the intestinal-type are translated to gastric adenocarcinoma in general; thus, the peculiarities of the diffuse-type are underappreciated.
RESULTS
Besides its growing importance, there are many gaps about the diffuse-type carcinogenesis and, as a result, its epidemiologic and pathogenetic features remain poorly understood.
CONCLUSIONS
Alternative hypotheses to explain these features are discussed, including the role of the gastric microbiota, medical therapies, and modifications in the stomach's microenvironment.
背景
肠型和弥漫型胃腺癌在临床、流行病学和分子特征上存在差异。然而，与肠型相关的大多数概念通常都被译为胃腺癌；因此，弥漫型的特殊性被低估了。
结果
除了其日益重要性之外，弥漫型癌发生学方面还存在许多空白，因此，其流行病学和发病机制特征仍未被充分理解。
结论
讨论了一些解释这些特征的替代假说，包括胃微生物群、医学治疗以及胃微环境改变的作用。
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