1Université de Franche Comté, UMR INSERM 1322 LINC, F-25000, Besançon, France.
2Centre hospitalier universitaire de Besançon, département clinique de psychiatrie, 25000, Besançon, France.
J Behav Addict. 2024 Sep 4;13(3):768-778. doi: 10.1556/2006.2024.00048. Print 2024 Oct 4.
Gambling activity evolves along a continuum from recreational to Gambling Disorder (GD) and a particular challenge is to identify whether there are some neurophysiological particularities already present in gamblers at an early stage. Our main goal was to determine whether, in the gamblers' population, neural responses generated during uncertain decisions were different depending on problematic gambling risk defined by the Canadian Problem Gambling Index (CPGI). We tested the following hypothesis, that the Problem Gambling group would show a different brain activity related to outcomes processing than people with low risk.
For this purpose, we established a relatively homogeneous population of Online Poker Players divided into two groups according to the CPGI (Low Risk and Problem Gambling). By means of high-density EEG, we compared the spatio-temporal dynamics generated during the completion of the Iowa Gambling Task.
One specific topographic map was observed between 150-175 ms after a negative outcome for both groups, whereas it was displayed in the win condition only for the Problem Gambling group. We found that the Global Field Power of this map was negatively correlated with participants' adherence to a strategy. Source localization identified Anterior Cingulate Cortex and Temporal regions as generators of this map.
Reward hypersensitivity EEG responses identified in the early outcome process could constitute a potential biomarker of problematic gambling.
赌博活动沿着从娱乐性到赌博障碍（GD）的连续体发展，一个特别的挑战是确定是否在早期阶段就存在一些神经生理学的特殊性。我们的主要目标是确定在赌徒群体中，在不确定的决策过程中产生的神经反应是否因加拿大赌博问题指数（CPGI）定义的赌博问题风险而有所不同。我们测试了以下假设，即有问题赌博组的人在处理结果时的大脑活动与低风险人群不同。
为此，我们建立了一个相对同质的在线扑克玩家群体，根据 CPGI（低风险和有问题的赌博）分为两组。通过高密度 EEG，我们比较了在完成爱荷华赌博任务期间产生的时空动态。
在两组中，在出现负面结果后 150-175 毫秒之间观察到一个特定的地形图，而在有问题的赌博组中仅在赢的情况下显示。我们发现，该地图的全局场强与参与者对策略的坚持呈负相关。源定位确定了前扣带回皮质和颞区作为该地图的产生源。
在早期结果过程中识别出的奖励过度敏感 EEG 反应可能是有问题赌博的潜在生物标志物。
