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一项职业创造力的全基因组关联研究及其与幸福感和职业成功的关系。

A genome-wide association study of occupational creativity and its relations with well-being and career success.

机构信息

Department of Management, CUHK Business School, The Chinese University of Hong Kong, Hong Kong, China.

Department of Human Resource Management, School of Business, Shanghai University of Finance and Economics, Shanghai, China.

出版信息

Commun Biol. 2024 Sep 5;7(1):1092. doi: 10.1038/s42003-024-06686-5.

DOI:10.1038/s42003-024-06686-5
PMID:39237691
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11377709/
Abstract

Creativity is one defining characteristic of human species. There have been mixed findings on how creativity relates to well-being, and little is known about its relationship with career success. We conduct a large-scale genome-wide association study to examine the genetic architecture of occupational creativity, and its genetic correlations with well-being and career success. The SNP-h estimates range from 0.08 (for managerial creativity) to 0.22 (for artistic creativity). We record positive genetic correlations between occupational creativity with autism, and positive traits and well-being variables (e.g., physical height, and low levels of neuroticism, BMI, and non-cancer illness). While creativity share positive genetic overlaps with indicators of high career success (i.e., income, occupational status, and job satisfaction), it also has a positive genetic correlation with age at first birth and a negative genetic correlation with number of children, indicating creativity-related genes may reduce reproductive success.

摘要

创造力是人类物种的一个显著特征。创造力与幸福感的关系存在混合的研究结果,而其与职业成功的关系则知之甚少。我们进行了一项大规模的全基因组关联研究,以检验职业创造力的遗传结构,以及其与幸福感和职业成功的遗传相关性。SNP-h 估计值范围从 0.08(管理创造力)到 0.22(艺术创造力)。我们记录了职业创造力与自闭症、积极特质和幸福感变量(例如,身高和神经质、BMI 和非癌症疾病水平较低)之间的正遗传相关性。虽然创造力与高职业成功的指标(即收入、职业地位和工作满意度)存在正遗传重叠,但它与初育年龄也存在正遗传相关性,与子女数量存在负遗传相关性,这表明与创造力相关的基因可能会降低生殖成功率。

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本文引用的文献

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Cross-trait assortative mating is widespread and inflates genetic correlation estimates.跨性状同型交配普遍存在,并夸大了遗传相关估计值。
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Is an elevated family-genetic risk for major psychiatric disorders specific to creative occupations?主要精神障碍的家族遗传风险升高是否仅存在于创造性职业中?
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