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一例浸润性导管癌转移至膀胱的乳腺癌病例报告。

A case report of breast cancer metastasis to the bladder from invasive ductal carcinoma.

作者信息

Hou Tian, Shen Guangtai, Hu Xin, Bai Tubuxin, He Heping, Zhang Zhipeng, Bao Wenqi, Tian Ruibo, Yu Xiaoqiang, Sun Tianyang, Ding Xiaoli, Wang Xin, Zhang Yuhai

机构信息

Department of Breast Surgery, Hinggan League People's Hospital, Ulanhot City.

Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

出版信息

Ann Med Surg (Lond). 2024 Jul 11;86(9):5529-5534. doi: 10.1097/MS9.0000000000002352. eCollection 2024 Sep.

Abstract

INTRODUCTION AND IMPORTANCE

Breast cancer is the most common malignancy among women worldwide, predominantly manifesting as invasive ductal carcinoma (IDC), which usually metastasizes to the bones, lungs, and liver. However, metastasis to the bladder is exceedingly rare, with few documented cases and limited understanding in the existing literature.

CASE PRESENTATION

A 57-year-old woman with a history of IDC presented with a lump in her left breast and was initially treated with chemotherapy and a modified radical mastectomy. Years later, she developed urinary symptoms, which upon investigation revealed multiple bladder tumors and right kidney hydronephrosis. Diagnostic imaging, including ultrasound and computed tomography (CT) scans, supported these findings.

CLINICAL DISCUSSION

The discovery of bladder metastasis from IDC highlights significant diagnostic challenges due to the atypical presentation. The case underscores the importance of considering unusual metastatic sites in patients with known breast cancer, especially when they present with non-specific urinary symptoms. This report explores the potential pathophysiological mechanisms of such rare metastatic occurrences and discusses the implications for clinical practice.

CONCLUSION

This case exemplifies the critical need for heightened awareness and thorough evaluation in patients with unusual symptoms and a history of breast cancer. It calls for more comprehensive diagnostic approaches and possibly adjusted treatment protocols to better manage atypical metastases, ultimately aiming to improve patient outcomes and contribute to a deeper understanding of metastatic breast cancer behavior.

摘要

引言与重要性

乳腺癌是全球女性中最常见的恶性肿瘤,主要表现为浸润性导管癌(IDC),通常会转移至骨骼、肺部和肝脏。然而,转移至膀胱极为罕见,仅有少数病例报道,现有文献对此了解有限。

病例介绍

一名有浸润性导管癌病史的57岁女性因左侧乳房肿块就诊,最初接受了化疗和改良根治性乳房切除术。数年后,她出现泌尿系统症状,检查发现多个膀胱肿瘤和右肾积水。包括超声和计算机断层扫描(CT)在内的诊断性影像学检查支持了这些发现。

临床讨论

浸润性导管癌发生膀胱转移的发现凸显了因表现不典型而带来的重大诊断挑战。该病例强调了在已知患有乳腺癌的患者中考虑不寻常转移部位的重要性,尤其是当他们出现非特异性泌尿系统症状时。本报告探讨了这种罕见转移情况的潜在病理生理机制,并讨论了其对临床实践的影响。

结论

该病例表明,对于有不寻常症状且有乳腺癌病史的患者,提高认识并进行全面评估至关重要。这需要更全面的诊断方法,并可能调整治疗方案,以更好地管理非典型转移,最终目标是改善患者预后,并有助于更深入地了解转移性乳腺癌的行为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e61/11374279/7e71a511bedd/ms9-86-5529-g001.jpg

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