Department of Neurology, Firoozgar Hospital, School of Medicine, Iran university of medical sciences, Tehran, Iran.
Neurosciences Department, St Vincents Hospital, Melbourne, Australia.
Hum Vaccin Immunother. 2022 Nov 30;18(5):2045153. doi: 10.1080/21645515.2022.2045153. Epub 2022 Mar 3.
Guillain-Barré syndrome (GBS) is an acute inflammatory polyradiculoneuropathy. In two-thirds of patients, it is preceded by an upper respiratory or gastrointestinal tract infection. Temporally associated cases of GBS following COVID-19 vaccination have been described with different COVID-19 vaccines. In this study, we report three cases of GBS patients following COVID-19 vaccine. Two of the studied patients received the Sinopharm vaccine and one patient received the AstraZeneca vaccine. All patients were diagnosed with acute motor axonal neuropathy (AMAN) type of GBS, on nerve conduction studies. All three patients responded well to treatment with intravenous immunoglobulin (IVIg). The association between COVID-19 vaccination and GBS is not well understood and more studies are needed to establish whether it is merely an association or a causal relationship.
格林-巴利综合征（GBS）是一种急性炎症性多神经根神经病。三分之二的患者在发病前有上呼吸道或胃肠道感染。在接种 COVID-19 疫苗后，不同的 COVID-19 疫苗与 GBS 出现时间相关的病例已有描述。在这项研究中，我们报告了三例 COVID-19 疫苗接种后出现 GBS 的病例。两名研究患者接种了国药疫苗，一名患者接种了阿斯利康疫苗。所有患者在神经传导研究中均被诊断为急性运动轴索性神经病（AMAN）型 GBS。所有三名患者均对静脉注射免疫球蛋白（IVIg）治疗反应良好。COVID-19 疫苗接种与 GBS 之间的关联尚不清楚，需要更多的研究来确定这仅仅是一种关联还是因果关系。
