Korean Medicine (KM) Data Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
Sci Data. 2024 Sep 6;11(1):974. doi: 10.1038/s41597-024-03734-x.
Traditional herbal medicine, rooted in a long history of use in East Asia, combines several herbs to create treatments showing high efficacy with minimal side effects, for specific diseases. Such combination therapies represent a potential reservoir of new drugs for treating multifactorial and incurable chronic diseases. However, the complexity of their mechanisms of action due to the combination of multiple compounds, has limited their research integration into modern pharmacological science. To address this challenge, we constructed drug-induced transcriptome data for herbal medicines through systematic experiments, analyzed with the aid of various omics databases. We introduce KORE-Map 1.0 (Korean medicine Omics Resource Extension Map), the first comprehensive resource of drug-derived transcriptome data for representative tonifying herbal medicines, effective in enhancing the immune system. This dataset aims to provide novel insights into the combinatorial mechanisms of these herbal medicines and to aid in the discovery of new therapeutic targets and indications for various incurable diseases.
传统草药医学根植于东亚长期使用的历史，将几种草药结合起来，为特定疾病创造出疗效高、副作用小的治疗方法。这种组合疗法代表了治疗多因素和无法治愈的慢性疾病的新药的潜在来源。然而，由于多种化合物的组合，其作用机制的复杂性限制了它们在现代药理学科学中的研究整合。为了解决这一挑战，我们通过系统实验构建了草药的药物诱导转录组数据，并借助各种组学数据库进行了分析。我们引入了 KORE-Map 1.0（韩国医学组学资源扩展图谱），这是第一个针对具有代表性的免疫增强型滋补草药的药物衍生转录组数据的综合资源。该数据集旨在为这些草药的组合机制提供新的见解，并有助于发现各种无法治愈的疾病的新治疗靶点和适应症。
