Department of Pharmaceutics, Department of Pharmacy, Sarala Birla University, Birla Knowledge City, Ranchi 835103, Jharkhand, India.
Department of Pharmaceutical Quality Assurance, Department of Pharmacy, Sarala Birla University, Birla Knowledge City, Ranchi 835103, Jharkhand, India; Department of Pharmaceutical Quality Assurance, Florence College of Pharmacy, IRBA, Ranchi, 835103, Jharkhand, India.
Int J Biol Macromol. 2024 Nov;279(Pt 3):135410. doi: 10.1016/j.ijbiomac.2024.135410. Epub 2024 Sep 6.
Wound healing is an intricate multifactorial process that may alter the extent of scarring left by the wound. A substantial portion of the global population is impacted by non-healing wounds, imposing significant financial burdens on the healthcare system. The conventional dosage forms fail to improve the condition, especially in the presence of other morbidities. Thus, there is a pressing requirement for a type of wound dressing that can safeguard the wound site and facilitate skin regeneration, ultimately expediting the healing process. In this context, Chondroitin sulfate (CS), a sulfated glycosaminoglycan material, is capable of hydrating tissues and further promoting the healing. Thus, this comprehensive review article delves into the recent advancement of CS-based hydrogel/scaffolds for wound healing management. The article initially summarizes the various physicochemical characteristics and sources of CS, followed by a brief understanding of the importance of hydrogel and CS in tissue regeneration processes. This is the first instance of such a comprehensive summarization of CS-based hydrogel/scaffolds in wound healing, focusing more on the mechanistic wound healing process, furnishing the recent innovations and toxicity profile. This contemporary review provides a profound acquaintance of strategies for contemporary challenges and future direction in CS-based hydrogel/scaffolds for wound healing.
伤口愈合是一个复杂的多因素过程，可能会改变伤口留下的疤痕程度。全球相当一部分人口受到非愈合性伤口的影响，这给医疗保健系统带来了巨大的经济负担。传统的剂型无法改善这种状况，特别是在存在其他疾病的情况下。因此，迫切需要一种能够保护伤口部位并促进皮肤再生的伤口敷料，从而加速愈合过程。在这种情况下，硫酸软骨素 (CS) 是一种硫酸化糖胺聚糖物质，能够使组织保持水分并进一步促进愈合。因此，本文深入探讨了基于 CS 的水凝胶/支架在伤口愈合管理方面的最新进展。文章首先总结了 CS 的各种物理化学特性和来源，然后简要了解了水凝胶和 CS 在组织再生过程中的重要性。这是首次对基于 CS 的水凝胶/支架在伤口愈合中的应用进行全面总结，重点关注机械性伤口愈合过程，提供了最新的创新和毒性概况。本综述为 CS 基水凝胶/支架在伤口愈合方面的当代挑战和未来方向提供了深刻的认识。
