Nakanishi Toshiyuki, Harada Taku, Nakai Mori, Kutsuna Satoshi
Department of Infectious Disease, Osaka University Hospital, Osaka, Japan.
Department of General Medicine, Nerima Hikarigaoka Hospital, Tokyo, Japan.
IDCases. 2024 Aug 8;37:e02056. doi: 10.1016/j.idcr.2024.e02056. eCollection 2024.
Disulfiram-like reactions occur when alcohol is consumed concurrently with certain drugs and can sometimes be fatal. Some cephalosporins such as cefoperazone could cause disulfiram-like reaction, known as cephalosporin-induced disulfiram-like reactions (CIDLRs). We describe a case of cefmetazole (CMZ)-treated CIDLR triggered by alcohol consumption. A 72-year-old Japanese man, treated with CMZ for perforated appendicitis and subsequent paralytic ileus, presented with skin flushing and chest discomfort, developing 30 min after consuming usual meals and alcohol. CIDLR was diagnosed due to recent use of CMZ and the symptoms alleviated without any medication. This is the first case report of a CMZ-induced disulfiram-like reaction.
当酒精与某些药物同时服用时会发生双硫仑样反应，有时可能会致命。一些头孢菌素如头孢哌酮可引起双硫仑样反应，称为头孢菌素诱导的双硫仑样反应（CIDLRs）。我们描述了一例因饮酒引发的头孢美唑（CMZ）治疗导致的CIDLRs病例。一名72岁的日本男性因穿孔性阑尾炎及随后的麻痹性肠梗阻接受CMZ治疗，在食用平常餐食和饮酒30分钟后出现皮肤潮红和胸部不适。由于近期使用了CMZ且症状未经任何药物治疗而缓解，故诊断为CIDLRs。这是首例CMZ诱导的双硫仑样反应的病例报告。
