National Anti-Tuberculosis Center, National Tuberculosis Control Program, Niamey, Niger.
Laboratory of Molecular Genetics and Genome analysis, Faculty of Science and Technology, University of Abomey-Calavi, UAC, Cotonou, Benin.
Pan Afr Med J. 2024 Apr 29;47:214. doi: 10.11604/pamj.2024.47.214.38442. eCollection 2024.
tuberculosis remains a major public health problem, with continuing high levels of prevalence, and mortality. In Niger, the incidence of tuberculosis remains high. This study aims to investigate the epidemiology of pulmonary tuberculosis at the National Anti-Tuberculosis Center of Niamey in Niger.
this study used a quantitative approach with a retrospective and descriptive design. Data were obtained from positive pulmonary tuberculosis cases detected by microscopy on Ziehl-Neelsen stained sputum at the National Anti-Tuberculosis Center (NATC) in Niamey, Niger covered the period between June 2017 and January 2020. 955 pulmonary TB patients were recorded whose diagnosis was based either on clinical-radiological arguments (thus negative microscopy) or positive microscopy. This form was used to collect data recorded in the clinical case registers, registers, and Excel files of the GeneXpert platform of the NATC laboratory.
eighty-nine-point eleven percent (89.11%) of the patients were microscopy-positive. Among the study population, men were the most affected by tuberculosis with 80.03%. The 25-34 age group, representing 23.77%, was the most affected. 6.93% of patients were co-infected with tuberculosis and HIV. All patients were put on treatment, with a therapeutic success rate of 72.38% and a therapeutic failure rate of 10.95%. Among the cases of therapeutic failure, 80.90% had Mycobacterium tuberculosis complex detected and 27.14% were resistant to Rifampicin.
Niger continues to have a tuberculosis epidemic which requires monitoring. Improving the diagnostic system for more effective management of the disease is important for appropriate diagnosis and treatment.
结核病仍然是一个主要的公共卫生问题，其患病率和死亡率持续居高不下。在尼日尔，结核病的发病率仍然很高。本研究旨在调查尼日尔尼亚美国家结核病防治中心的肺结核流行病学。
本研究采用定量方法，回顾性和描述性设计。数据来自于 2017 年 6 月至 2020 年 1 月期间在尼日尔尼亚美国家结核病防治中心（NATC）通过显微镜检查发现的涂 Ziehl-Neelsen 染色痰液的阳性肺结核病例。共记录了 955 例肺结核患者，其诊断依据是临床-影像学依据（因此显微镜检查为阴性）或显微镜检查阳性。该表格用于收集 NATC 实验室 GeneXpert 平台的临床病例登记册、登记册和 Excel 文件中记录的数据。
89.11%的患者显微镜检查阳性。在研究人群中，男性受结核病影响最大，占 80.03%。25-34 岁年龄组（占 23.77%）受影响最大。6.93%的患者同时感染结核病和艾滋病病毒。所有患者均接受治疗，治疗成功率为 72.38%，治疗失败率为 10.95%。在治疗失败的病例中，有 80.90%检测到结核分枝杆菌复合体，27.14%对利福平耐药。
尼日尔仍存在结核病流行，需要进行监测。改善诊断系统对于更有效地管理该疾病非常重要，有助于进行适当的诊断和治疗。
