Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325001, China.
Small. 2024 Nov;20(48):e2405847. doi: 10.1002/smll.202405847. Epub 2024 Sep 9.
Microneedles are demonstrated as an effective strategy for chronic wound treatment. Great endeavors are devoted to developing microneedles with natural compositions and potent functions to promote therapeutic effects for wound healing. Herein, a novel graphene oxide-integrated methacrylated fish gelatin (GO-FGelMA) microneedle patch encapsulated with bacitracin and vascular endothelial growth factor (VEGF) is developed for chronic wound management. As the natural components and porous structures of FGelMA, the fabricated microneedle patches display satisfactory biocompatibility and drug-loading ability. Owing to the integration of graphene oxide, the microneedle patches can realize promoted drug release via near-infrared (NIR) irradiation. Besides, the encapsulated bacitracin and VEGF endow the microneedle patches with the ability to inhibit bacterial growth and promote angiogenesis. It is demonstrated that the GO-FGelMA microneedle patches with efficient drug release exert a positive influence on the wound healing process through reduced inflammation, enhanced wound closure, and improved tissue regeneration. Thus, it is believed that the proposed drugs-loaded GO-FGelMA microneedle patches will hold great potential in future chronic wound treatment.
微针被证明是一种有效的慢性伤口治疗策略。人们致力于开发具有天然成分和强大功能的微针，以促进伤口愈合的治疗效果。本文开发了一种新型的氧化石墨烯整合甲基丙烯酰化鱼明胶（GO-FGelMA）微针贴片，该贴片包封了杆菌肽和血管内皮生长因子（VEGF），用于慢性伤口管理。由于 FGelMA 的天然成分和多孔结构，所制备的微针贴片显示出良好的生物相容性和药物负载能力。由于氧化石墨烯的整合，微针贴片可以通过近红外（NIR）照射实现药物的促进释放。此外，包封的杆菌肽和 VEGF 使微针贴片具有抑制细菌生长和促进血管生成的能力。研究表明，具有高效药物释放的 GO-FGelMA 微针贴片通过减少炎症、增强伤口闭合和改善组织再生，对伤口愈合过程产生积极影响。因此，我们相信负载药物的 GO-FGelMA 微针贴片在未来的慢性伤口治疗中具有巨大的潜力。
