Shu Wen, Li Menglong, Vermund Sten H, Li Hui, Hu Yifei
Department of Growth and Development, Capital Institute of Pediatrics, Beijing, 100020, China.
Children's Hospital Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
Heliyon. 2024 Aug 15;10(16):e36381. doi: 10.1016/j.heliyon.2024.e36381. eCollection 2024 Aug 30.
Nutritional status significantly impacts linear bone growth. We aimed to determine the relationship between the trajectories of four body composition indicators and pubertal advanced bone age. Trajectories of body mass index z-score (BMI z-score), visceral fat area z-score (VFA z-score), fat mass index z-score (FMI z-score), and fat-free mass index z-score (FFMI z-score) were identified based on three body composition measurements conducted from October 2018 to April 2023 within a pediatric cohort (the PROC study). We assessed pubertal bone age using the Tanner-Whitehouse 3-Chinese Radius-Ulna-Short (TW3-C RUS) method among 1402 primary school children. Children with a trajectory of higher BMI z-score, VFA z-score, FMI z-score, and FFMI z-score since childhood were more likely to have advanced bone age. The risk of advanced bone age was higher in children who were consistently in the high VFA z-score group (odds ratio [OR] = 6.73) or consistently in the high BMI z-score group (OR = 5.57), as compared to those in the low VFA z-score and low BMI z-score groups. Regular monitoring and maintenance of normal VFA during childhood may reduce the risk of advanced bone age at puberty. Furthermore, BMI monitoring is optional, especially in cases where specialized body composition equipment is not available.
营养状况对骨骼线性生长有显著影响。我们旨在确定四项身体成分指标的变化轨迹与青春期骨龄提前之间的关系。基于2018年10月至2023年4月在一个儿科队列（PROC研究）中进行的三次身体成分测量，确定了体重指数z评分（BMI z评分）、内脏脂肪面积z评分（VFA z评分）、脂肪量指数z评分（FMI z评分）和去脂体重指数z评分（FFMI z评分）的变化轨迹。我们使用坦纳 - 怀特豪斯3 - 中国桡骨 - 尺骨 - 短骨（TW3 - C RUS）方法对1402名小学生的青春期骨龄进行了评估。自童年起BMI z评分、VFA z评分、FMI z评分和FFMI z评分变化轨迹较高的儿童更有可能出现骨龄提前。与低VFA z评分组和低BMI z评分组的儿童相比，持续处于高VFA z评分组（优势比[OR]=6.73）或持续处于高BMI z评分组（OR = 5.57）的儿童骨龄提前的风险更高。在儿童期定期监测并维持正常的VFA可能会降低青春期骨龄提前的风险。此外，BMI监测是可选的，特别是在没有专门身体成分测量设备的情况下。
