School of Medicine, Shanghai University, Shanghai 200444, China.
School of Mechatronic Engineering and Automation, Shanghai University, Shanghai 200444, China.
ACS Biomater Sci Eng. 2024 Oct 14;10(10):6097-6119. doi: 10.1021/acsbiomaterials.4c01378. Epub 2024 Sep 10.
Mussel refers to a marine organism with strong adhesive properties, and it secretes mussel adhesion protein (MAP). The most vital feature of MAP is the abundance of the 3,4-dihydroxyphenylalanine (DOPA) group and lysine, which have antimicrobial, anti-inflammatory, antioxidant, and cell adhesion-promoting properties and can accelerate wound healing. Polydopamine (PDA) is currently the most widely used mussel-inspired material characterized by good adhesion, biocompatibility, and biodegradability. It can mediate various interactions to form functional coatings on cell-material surfaces. Nanofibers based on MAP and mussel-inspired materials have been exerting a vital role in wound repair, while there is no comprehensive review presenting them. This Review introduces the structure of MAPs and their adhesion mechanisms and mussel-inspired materials. Second, it introduces the functionalized modification of MAPs and their inspired materials in electrospun nanofibers and application in wound repair. Finally, the future development direction and coping strategies of MAP and mussel-inspired materials are discussed. Moreover, this Review can offer novel strategies for the application of nanofibers in wound repair and bring about new breakthroughs and innovations in tissue engineering and regenerative medicine.
贻贝是一种具有很强粘附特性的海洋生物，它分泌贻贝粘附蛋白（MAP）。MAP 最重要的特点是富含 3,4-二羟基苯丙氨酸（DOPA）和赖氨酸，具有抗菌、抗炎、抗氧化和促进细胞黏附的特性，可以加速伤口愈合。聚多巴胺（PDA）是目前应用最广泛的受贻贝启发的材料，具有良好的粘附性、生物相容性和可生物降解性。它可以介导各种相互作用，在细胞-材料表面形成功能性涂层。基于 MAP 和受贻贝启发的材料的纳米纤维在伤口修复中发挥着重要作用，但目前尚无综合综述对其进行介绍。本文综述了 MAP 的结构及其粘附机制和受贻贝启发的材料。其次，介绍了 MAP 及其受贻贝启发的材料在静电纺纳米纤维中的功能化修饰及其在伤口修复中的应用。最后，讨论了 MAP 和受贻贝启发的材料的未来发展方向和应对策略。此外，本文综述可为纳米纤维在伤口修复中的应用提供新的策略，为组织工程和再生医学带来新的突破和创新。
