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应用交流生物磁强计评估和成像肝硬化模型中磁性纳米颗粒的生物分布。

Evaluation and imaging of biodistribution of magnetic nanoparticles in a model of hepatic cirrhosis via alternating current biosusceptometry.

机构信息

Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu, 18618-689, SP, Brazil.

Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu, 18618-689, SP, Brazil.

出版信息

Biomed Phys Eng Express. 2024 Sep 20;10(6). doi: 10.1088/2057-1976/ad795b.

DOI:10.1088/2057-1976/ad795b
PMID:39260388
Abstract

In recent years, magnetic nanoparticles (MNPs) have exhibited theragnostic characteristics which confer a wide range of applications in the biomedical field. Consequently, through Alternating Current Biosusceptometry (ACB), magnetic nanoparticles can be used as tracers, allowing the study of healthy and cirrhotic livers and providing the ability to differentiate them through the reconstruction of quantitative images. The ACB system consists of a developing biomagnetic technique that has the ability to magnetize and measure the magnetic susceptibility of a material such as MNPs, thereby offering quantitative information about biological systems with magnetic tracers.

摘要

近年来,磁性纳米粒子(MNPs)表现出了诊断-治疗特性,这使得它们在生物医学领域有了广泛的应用。因此,通过交流生物磁测量(ACB),磁性纳米粒子可以作为示踪剂,用于研究健康和肝硬化的肝脏,并通过重建定量图像来区分它们。ACB 系统由一种发展中的生物磁技术组成,该技术能够使 MNPs 等材料磁化并测量其磁化率,从而为带有磁性示踪剂的生物系统提供定量信息。

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