IEEE Trans Nanobioscience. 2019 Jul;18(3):456-462. doi: 10.1109/TNB.2019.2912073. Epub 2019 Apr 18.
In this paper, the application of a technique to evaluate in vivo biodistribution of magnetic nanoparticles (MNP) is addressed: the Multichannel AC Biosusceptometry System (MC-ACB). It allows real-time assessment of magnetic nanoparticles in both bloodstream clearance and liver accumulation, where a complex network of inter-related cells is responsible for MNP uptake. Based on the acquired MC-ACB images, we propose a mathematical model which helps to understand the distribution and accumulation pharmacokinetics of MNP. The MC-ACB showed a high time resolution to detect and monitor MNP, providing sequential images over the particle biodistribution. Utilizing the MC-ACB instrument, we assessed regions corresponding to the heart and liver, and we determined the MNP transfer rates between the bloodstream and the liver. The pharmacokinetic model resulted in having a strong correlation with the experimental data, suggesting that the MC-ACB is a valuable and accessible imaging device to assess in vivo and real-time pharmacokinetic features of MNP.
本文介绍了一种用于评估体内磁性纳米颗粒（MNP）生物分布的技术：多通道交流生物磁强计系统（MC-ACB）。该技术可实时评估血液清除和肝脏积累过程中的磁性纳米颗粒，因为肝脏中存在一个负责摄取 MNP 的复杂细胞网络。基于所获得的 MC-ACB 图像，我们提出了一个数学模型，有助于理解 MNP 的分布和积累药代动力学。MC-ACB 具有很高的时间分辨率，可用于检测和监测 MNP，提供粒子生物分布的连续图像。我们利用 MC-ACB 仪器评估了对应于心脏和肝脏的区域，并确定了血液和肝脏之间的 MNP 转移速率。药代动力学模型与实验数据具有很强的相关性，这表明 MC-ACB 是一种有价值且易于使用的成像设备，可用于评估 MNP 的体内实时药代动力学特征。
