Departamento de Física e Biofísica, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
Departamento de Fisiologia, IBB, Universidade Estadual Paulista, Botucatu, São Paulo, 18618-689, Brazil.
Nanomedicine (Lond). 2020 Feb;15(5):511-525. doi: 10.2217/nnm-2019-0300. Epub 2020 Feb 20.
This paper aims to investigate a doxorubicin (DOX) chronic kidney disease rat model using magnetic nanoparticles (MNPs) associated with the alternate current biosusceptometry (ACB) to analyze its different perfusion profiles in both healthy and DOX-injured kidneys. We used the ACB to detect the MNP kidney perfusion . Furthermore, we performed biochemical and histological analyses, which sustained results obtained from the ACB system. We also studied the MNP biodistribution. We found that DOX kidney injury alters the MNPs' kidney perfusion. These changes became more intense as the disease progressed. Moreover, DOX has an important effect on MNP biodistribution as the disease evolved. This study provides new applications of MNPs in nephrology, instrumentation, pharmacology, physiology and nanomedicine.
本研究旨在利用磁性纳米颗粒（MNPs）联合交流生物磁测量法（ACB）建立多柔比星（DOX）慢性肾病大鼠模型，分析其在健康和 DOX 损伤肾脏中的不同灌注特征。我们使用 ACB 检测 MNPs 的肾脏灌注。此外，我们进行了生化和组织学分析，这些分析结果与 ACB 系统的结果一致。我们还研究了 MNPs 的生物分布。我们发现 DOX 肾损伤改变了 MNPs 的肾脏灌注。随着疾病的进展，这些变化变得更加明显。此外，随着疾病的进展，DOX 对 MNP 生物分布有重要影响。本研究为 MNPs 在肾病学、仪器仪表、药理学、生理学和纳米医学中的应用提供了新的思路。
