Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada.
Transl Res. 2024 Dec;274:35-48. doi: 10.1016/j.trsl.2024.09.001. Epub 2024 Sep 10.
Gastric cancer is a major health concern worldwide. The survival rate of Gastric cancer greatly depends on the stage at which it is diagnosed. Early diagnosis is critical for improving survival outcomes. To improve the chances of early diagnosis, regular screening tests, such as an upper endoscopy or barium swallow, are recommended for individuals at a higher risk due to factors like family history or a previous diagnosis of gastric conditions. Biomarkers can be detected and measured using non-invasive methods such as blood tests, urine tests, breath analysis, or imaging techniques. These non-invasive approaches offer many advantages, including convenience, safety, and cost-effectiveness, making them valuable tools for disease diagnosis, monitoring, and research. Biomarker-based tests have emerged as a useful tool for identifying gastric cancer early, monitoring treatment response, assessing the recurrence risk, and personalizing treatment plans. In this current review, we have explored both classical and novel biomarkers for gastric cancer. We have centralized their potential clinical application and discussed the challenges in Gastric cancer research.
胃癌是全球范围内的一个主要健康关注点。胃癌的存活率在很大程度上取决于诊断时的阶段。早期诊断对于改善生存结果至关重要。为了提高早期诊断的机会，对于因家族史或以前的胃部疾病诊断等因素而处于较高风险的个体，建议进行常规的筛查测试，如上内窥镜检查或钡餐检查。可以使用非侵入性方法（如血液检查、尿液检查、呼吸分析或成像技术）检测和测量生物标志物。这些非侵入性方法具有许多优点，包括方便、安全和具有成本效益，使其成为疾病诊断、监测和研究的有价值的工具。基于生物标志物的测试已成为早期识别胃癌、监测治疗反应、评估复发风险和制定个体化治疗计划的有用工具。在本综述中，我们探讨了用于胃癌的经典和新型生物标志物，集中讨论了它们在胃癌研究中的潜在临床应用和面临的挑战。
