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韩国红参通过下调细胞间黏附分子-1(ICAM-1)和血管细胞黏附分子-1(VCAM-1)改善FeCl诱导的动脉血栓形成的协同作用。

The synergistic effects of Korean Red Ginseng and ameliorating FeCl-induced arterial thrombosis by downregulating ICAM-1 and VCAM-1.

作者信息

Kwak Yi-Seong, Hossain Mohammad Amjad, Vijayakumar Ajay, Kang Chang Won, Park Chul, Park Sang-Youel, Kim Jong-Hoon

机构信息

R&D Headquarters, Korea Ginseng Corporation, Daejeon, Republic of Korea.

College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan-city, Republic of Korea.

出版信息

J Ginseng Res. 2024 Sep;48(5):520-523. doi: 10.1016/j.jgr.2024.06.001. Epub 2024 Jun 7.

DOI:10.1016/j.jgr.2024.06.001
PMID:39263303
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11385385/
Abstract

In this study, we compared antithrombotic activities of Korean Red Ginseng (KRG) and (CPC) on rats with induced thrombosis. Results indicate that KRG and CPC suppressed the arterial occlusion and the combination of KRG and CPC (KRG + CPC) treatment exhibited a synergistic effect with maximum reduction in thrombosis.

摘要

在本研究中,我们比较了高丽参(KRG)和复方丹参片(CPC)对诱导血栓形成大鼠的抗血栓活性。结果表明,KRG和CPC均抑制了动脉闭塞,并且KRG与CPC联合治疗(KRG + CPC)表现出协同作用,使血栓形成的减少达到最大程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/2a5a502ee19f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/9d8a714ce95f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/9ba4c3ef1564/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/2a5a502ee19f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/9d8a714ce95f/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/9ba4c3ef1564/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e35c/11385385/2a5a502ee19f/gr2.jpg

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本文引用的文献

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J Ginseng Res. 2024 May;48(3):323-332. doi: 10.1016/j.jgr.2024.01.003. Epub 2024 Jan 17.
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Novel insights on the role of VCAM-1 and ICAM-1: Potential biomarkers for cardiovascular diseases.关于血管细胞粘附分子-1(VCAM-1)和细胞间粘附分子-1(ICAM-1)作用的新见解:心血管疾病的潜在生物标志物
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Deer Velvet Antler Extracts Exert Anti-Inflammatory and Anti-Arthritic Effects on Human Rheumatoid Arthritis Fibroblast-Like Synoviocytes and Distinct Mouse Arthritis.鹿茸提取物对人类风湿关节炎成纤维样滑膜细胞和不同的关节炎鼠发挥抗炎和抗关节炎作用。
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