Department of Sports Medicine and Active Health Sciences, Faculty of Medicine in Pilsen, Charles University, Czech Republic,
Physiol Res. 2024 Aug 31;73(4):499-514. doi: 10.33549/physiolres.935331.
Once considered a metabolic waste product, today it is considered an important signaling molecule continuously forming under aerobic conditions. Lactate, a molecule primarily known as a byproduct of glycolysis, has gained importance in recent years due to its multifaceted role in various biological processes. Misconceptions surrounding lactate have persisted for centuries, especially the belief that elevated lactate levels were solely a result of low oxygen levels shaped early understanding. However, current research challenges this view and expands our comprehension of lactate's various roles. Unfortunately, despite all of the mentioned above lactate is rooted in modern society as a deterrent word and many people do not know its value in the human body, let alone clinical implementations or physical performance. The main goal of this review is to refresh current knowledge regarding lactate research and spread the overall information among a professional society. Key words: Lactate, Lactate metabolism, Lactic acid, Disease metabolism, Lactate shuttle.
曾经被认为是一种代谢废物,如今它被认为是在有氧条件下不断形成的重要信号分子。乳酸,一种主要作为糖酵解副产物的分子,近年来由于其在各种生物过程中的多方面作用而变得重要。围绕乳酸的误解已经存在了几个世纪,特别是认为升高的乳酸水平仅仅是低氧水平的结果,这一观点塑造了早期的理解。然而,目前的研究挑战了这一观点,并扩展了我们对乳酸各种作用的理解。不幸的是,尽管如上所述,乳酸在现代社会中仍然是一个令人望而却步的词,许多人不知道它在人体中的价值,更不用说临床实施或身体表现了。本次综述的主要目的是更新有关乳酸研究的现有知识,并在专业社会中传播整体信息。关键词:乳酸、乳酸代谢、乳酸、疾病代谢、乳酸穿梭。