Department of Food Analysis and Nutrition, University of Chemistry and Technology, Technická 5, 166 28 Prague 6, Czech Republic.
J Agric Food Chem. 2024 Sep 25;72(38):21254-21265. doi: 10.1021/acs.jafc.4c05940. Epub 2024 Sep 12.
Besides many other uses, dried may be used for "tea" preparation. This study focused on a comprehensive characterization of an aqueous infusion prepared according to a common practice from three fairly different cultivars. The transfer of 42 phytocannabinoids and 12 major bioactive compounds (flavonoids) into the infusion was investigated using UHPLC-HRMS/MS. Phytocannabinoid acids were transferred generally in a higher extent compared to their counterparts; in the case of Δ-THC, it was only in the range of 0.4-1.9% of content in the used. A dramatic increase of phytocannabinoids, mainly of the neutral species, occurred when cream was added during steeping, and the transfer of Δ-THC into "tea" achieved a range of 53-64%. Under such conditions, drinking a 250 mL cup of such tea by a 70 kg person might lead to multiple exceedance of the Acute Reference Dose (ARfD), 1 μg/kg b.w., even in the case when using hemp with a Δ-THC content below 1% in dry weight for preparation.
除了许多其他用途外，还可用于“茶”的制备。本研究集中于根据三种相当不同的品种植株的常见做法全面表征根据常见做法制备的水性汤剂。使用 UHPLC-HRMS/MS 研究了 42 种植物大麻素和 12 种主要生物活性化合物（类黄酮）转移到汤剂中的情况。与相应的物质相比，植物大麻素酸通常以更高的程度转移；在 Δ-THC 的情况下，它仅在所用中的含量范围为 0.4-1.9%。当在浸泡过程中添加奶油时，植物大麻素大量增加，主要是中性物质，并且 Δ-THC 转移到“茶”中的范围为 53-64%。在这种情况下，体重为 70 公斤的人饮用 250 毫升这种茶可能会导致多次超过急性参考剂量（ARfD），即 1μg/kg b.w.，即使使用干重中 Δ-THC 含量低于 1%的大麻来制备也是如此。
