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1
Induction of Kb-restricted anti-influenza cytotoxic T cells in C57BL mice: importance of stimulator cell type and immunization route.在C57BL小鼠中诱导Kb限制性抗流感细胞毒性T细胞：刺激细胞类型和免疫途径的重要性。
Immunology. 1985 Aug;55(4):601-7.
2
Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells.在缺乏I类限制性细胞毒性T细胞的情况下，小鼠可以从肺部流感病毒感染中恢复。
J Immunol. 1992 Jan 1;148(1):212-7.
3
Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses.肺部局部白细胞介素-4的表达会降低肺部流感病毒特异性继发性细胞毒性T细胞反应。
Virology. 2000 Mar 30;269(1):66-77. doi: 10.1006/viro.2000.0187.
4
Do L3T4+ T cells act as effector cells in protection against influenza virus infection.L3T4+ T细胞在抵抗流感病毒感染的过程中是否作为效应细胞发挥作用？
Immunology. 1987 Sep;62(1):139-44.
5
T lymphocyte responses to multiple minor histocompatibility antigens generate both self-major histocompatibility complex-restricted and cross-reactive cytotoxic T lymphocytes.T淋巴细胞对多种次要组织相容性抗原的反应会产生自身主要组织相容性复合体限制的和交叉反应性细胞毒性T淋巴细胞。
Transplantation. 1994 Jul 15;58(1):59-67.
6
Recognition of influenza-infected cells by cytolytic T lymphocyte clones: determinant selection by class I restriction elements.细胞溶解型T淋巴细胞克隆对流感感染细胞的识别：由I类限制元件进行决定簇选择。
J Immunol. 1983 Oct;131(4):1635-40.
7
Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.流感核蛋白特异性细胞毒性T细胞克隆在体内具有保护作用。
Immunology. 1986 Jul;58(3):417-20.
8
Cytotoxic T-memory cells in virus infection and the specificity of helper T cells.病毒感染中的细胞毒性T记忆细胞及辅助性T细胞的特异性
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9
Cross-reactivity patterns of influenza-specific cytotoxic T lymphocytes from H-2Kb mutant mice.来自H-2Kb突变小鼠的流感特异性细胞毒性T淋巴细胞的交叉反应模式。
J Immunol. 1983 Jul;131(1):471-4.
10
Genetic control of the induction of cytolytic T lymphocyte responses to AKR/Gross viral leukemias. II. Negative control by the Fv-1 locus in AKR mice of responder H-2b haplotype.对AKR/Gross病毒性白血病细胞毒性T淋巴细胞反应诱导的遗传控制。II. 应答性H-2b单倍型AKR小鼠中Fv-1基因座的负调控。
J Immunol. 1984 May;132(5):2665-71.

引用本文的文献

1
References.参考文献。
Perspect Med Virol. 1986;2:209-245. doi: 10.1016/S0168-7069(08)70043-0. Epub 2008 May 29.
2
Low responder MHC alleles for Tc recognition of influenza nucleoprotein.针对流感核蛋白的Tc识别的低反应性MHC等位基因。
Immunogenetics. 1986;23(6):379-84. doi: 10.1007/BF00372670.
3
Recognition of cloned vesicular stomatitis virus internal and external gene products by cytotoxic T lymphocytes.细胞毒性T淋巴细胞对克隆的水泡性口炎病毒内部和外部基因产物的识别。
J Exp Med. 1986 Jun 1;163(6):1529-38. doi: 10.1084/jem.163.6.1529.
4
Class I H-2d-restricted cytotoxic T lymphocytes recognize the neuraminidase glycoprotein of influenza virus subtype N1.I类H-2d限制性细胞毒性T淋巴细胞识别甲型流感病毒N1亚型的神经氨酸酶糖蛋白。
J Virol. 1990 Mar;64(3):1028-32. doi: 10.1128/JVI.64.3.1028-1032.1990.

本文引用的文献

1
H-2 expression by lymphoid cells of different mouse strains: quantitative interaction of H-2 with monoclonal antibodies and their Fab fragments.不同小鼠品系淋巴细胞的H-2表达：H-2与单克隆抗体及其Fab片段的定量相互作用。
Immunology. 1981 Feb;42(2):207-15.
2
Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line.一种克隆的T杀伤细胞系对不同甲型流感病毒的交叉反应性。
Nature. 1980 Nov 13;288(5787):164-5. doi: 10.1038/288164a0.
3
Limit-dilution analysis of weak influenza-immune T cell responses associated with H-2Kb and H-2Db.与H-2Kb和H-2Db相关的弱流感免疫T细胞反应的极限稀释分析。
J Immunol. 1982 Aug;129(2):689-93.
4
Absence of Ir gene control of T cells recognizing foreign antigen in the context of allogenic MHC molecules.在同种异体MHC分子的背景下，不存在Ir基因对识别外来抗原的T细胞的控制。
Nature. 1982 Feb 11;295(5849):531-3. doi: 10.1038/295531a0.
5
Identification of a second class I antigen controlled by the K end of the H-2 complex and its selective cellular expression.鉴定由H-2复合体K端控制的第二类I类抗原及其选择性细胞表达。
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1445-8. doi: 10.1073/pnas.80.5.1445.
6
Analysis of the cytotoxic T cell response to H-Y in CBA/H mice.CBA/H小鼠中细胞毒性T细胞对H-Y反应的分析。
J Immunol. 1981 Aug;127(2):681-5.
7
Neonatal tolerance of major histocompatibility complex antigens alters Ir gene control of the cytotoxic T cell response to vaccinia virus.主要组织相容性复合体抗原的新生儿耐受性改变了Ir基因对细胞毒性T细胞针对痘苗病毒反应的控制。
J Exp Med. 1983 Apr 1;157(4):1324-38. doi: 10.1084/jem.157.4.1324.
8
Most influenza A virus-specific memory cytotoxic T lymphocytes react with antigenic epitopes associated with internal virus determinants.大多数甲型流感病毒特异性记忆细胞毒性T淋巴细胞与与病毒内部决定簇相关的抗原表位发生反应。
J Exp Med. 1984 Feb 1;159(2):365-77. doi: 10.1084/jem.159.2.365.
9
Loss of serological determinants does not affect recognition of H-2Kk target cells by an influenza-specific cytotoxic T cell clone.血清学决定簇的丧失并不影响流感特异性细胞毒性T细胞克隆对H-2Kk靶细胞的识别。
Eur J Immunol. 1983 Sep;13(9):762-6. doi: 10.1002/eji.1830130912.
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The capacity of murine alveolar macrophages to stimulate antigen-dependent T-lymphocyte activation and proliferation.
Cell Immunol. 1983 Jul 15;79(2):374-82. doi: 10.1016/0008-8749(83)90079-5.

在C57BL小鼠中诱导Kb限制性抗流感细胞毒性T细胞：刺激细胞类型和免疫途径的重要性。

Induction of Kb-restricted anti-influenza cytotoxic T cells in C57BL mice: importance of stimulator cell type and immunization route.

作者信息

Pala P, Askonas B A

出版信息

Immunology. 1985 Aug;55(4):601-7.

PMID:3926637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1453774/
Abstract

C57BL/6 mice generate influenza-specific cytotoxic T cells (Tc) which are predominantly restricted to Db. The induction of a Kb-restricted response in H-2b mice has been controversial. We show here that the magnitude of Kb-restricted anti-influenza Tc responses is affected by the type of stimulator cell. Both in vivo and in vitro, secondary responses in the spleen show strong selection for Db-restricted Tc. However, limiting dilution analyses show that intranasal (i.n.) influenza infection primes Kb- as well as Db-restricted Tc in C57BL mice at a ratio of 1:2--but different cell types acting as stimulator cells vary in their ability to induce secondary Kb-restricted influenza-specific Tc (B lymphoblasts greater than macrophages greater than spleen cells greater than T lymphoblasts). Thus, the site of infection and antigen presentation can determine the MHC restriction of T-cell responses.

摘要

C57BL/6小鼠产生主要受Db限制的流感特异性细胞毒性T细胞（Tc）。在H-2b小鼠中诱导Kb限制的反应一直存在争议。我们在此表明，Kb限制的抗流感Tc反应的强度受刺激细胞类型的影响。在体内和体外，脾脏中的二次反应都表现出对Db限制的Tc有强烈的选择。然而，有限稀释分析表明，鼻内（i.n.）流感感染以1:2的比例在C57BL小鼠中引发Kb和Db限制的Tc——但作为刺激细胞的不同细胞类型在诱导二次Kb限制的流感特异性Tc的能力上有所不同（B淋巴母细胞大于巨噬细胞大于脾细胞大于T淋巴母细胞）。因此，感染部位和抗原呈递可以决定T细胞反应的MHC限制。