以“喂食”方式让癌症致死——三种芳香酸可抑制肿瘤生长。 - Suppr

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超能文献

Feeding cancer to death - a triad of aromatic acids reduces tumor growth.

作者信息

Xavier Audrey, Dikic Ivan

机构信息

Institute of Biochemistry II, Faculty of Medicine, Goethe University Frankfurt, Frankfurt am Main, Germany.

Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, Frankfurt am Main, Germany.

出版信息

Cell Death Differ. 2024 Oct;31(10):1239-1241. doi: 10.1038/s41418-024-01372-9. Epub 2024 Sep 12.

DOI:10.1038/s41418-024-01372-9

PMID:39266718

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11445509/

Abstract

摘要

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Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive.芳香族氨基酸或沉默 Sestrin3（其感应介质）抑制核质蛋白酶体易位是肿瘤抑制作用。

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Targeting hypoxia-inducible factors: therapeutic opportunities and challenges.靶向低氧诱导因子：治疗机会与挑战。

Nat Rev Drug Discov. 2024 Mar;23(3):175-200. doi: 10.1038/s41573-023-00848-6. Epub 2023 Dec 20.

Regulation of nucleo-cytosolic 26S proteasome translocation by aromatic amino acids via mTOR is essential for cell survival under stress.芳香族氨基酸通过 mTOR 调控核质 26S 蛋白酶体易位对于应激状态下细胞存活至关重要。

Mol Cell. 2023 Sep 21;83(18):3333-3346.e5. doi: 10.1016/j.molcel.2023.08.016.

Site-Specific Proteasome Inhibitors.靶向蛋白酶体抑制剂。

Biomolecules. 2021 Dec 31;12(1):54. doi: 10.3390/biom12010054.

Cellular quality control by the ubiquitin-proteasome system and autophagy.细胞的泛素-蛋白酶体系统和自噬的质量控制。

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