College of Food Science and Engineering, Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing 210023, China.
College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.
Food Funct. 2024 Sep 30;15(19):9972-9982. doi: 10.1039/d4fo02572e.
Food-derived nanomaterials optimizing bioactive peptides is an emerging route in the functional food field. Zein and gum arabic (GA) possess favorable encapsulation properties for controlled release, targeted delivery and stabilization of food bioactive ingredients, and thus are considered as promising carriers for delivery systems. In order to improve the bioavailability of rice selenium-containing peptide TSeMMM (T), the nanoparticles (ZTGNs) containing peptide T, zein and GA have been previously prepared. This study focused on evaluating the immunomodulatory capacity of ZTGNs. The results showed that ZTGNs significantly alleviated cyclophosphamide-induced reduction in immune organ indices and liver glutathione content of mice. There was a significant upregulation observed in the levels of immune-related cytokines IL-6, TNF-α, and IFN-γ as well as their mRNA expression. Moreover, ZTGNs enriched the diversity of the intestinal flora and promoted the proportion of beneficial bacteria. In conclusion, ZTGNs have potential as immunomodulatory enhancers for food bioactive ingredients, providing prospects for further optimization of dietary supplements.
食品源纳米材料优化生物活性肽是功能食品领域的一个新兴途径。玉米醇溶蛋白和阿拉伯胶（GA）具有良好的控制释放、靶向传递和稳定食品生物活性成分的包封性能，因此被认为是有前途的输送系统载体。为了提高含硒大米肽 TSeMMM（T）的生物利用度，先前已经制备了含有肽 T、玉米醇溶蛋白和 GA 的纳米颗粒（ZTGNs）。本研究重点评估了 ZTGNs 的免疫调节能力。结果表明，ZTGNs 显著减轻了环磷酰胺诱导的免疫器官指数和小鼠肝脏谷胱甘肽含量的降低。观察到免疫相关细胞因子 IL-6、TNF-α 和 IFN-γ及其 mRNA 表达水平显著上调。此外，ZTGNs 丰富了肠道菌群的多样性，并促进了有益细菌的比例。总之，ZTGNs 具有作为食品生物活性成分的免疫调节剂的潜力，为进一步优化膳食补充剂提供了前景。
