豚鼠经结核杆菌致敏后，胞壁酰二肽诱导的坏死性炎症反应。
Necrotic inflammatory reaction induced by muramyl dipeptide in guinea pigs sensitized by tubercle bacilli.
作者信息
Nagao S, Tanaka A
出版信息
J Exp Med. 1985 Aug 1;162(2):401-12. doi: 10.1084/jem.162.2.401.
In the course of studies aimed at determining whether MDP was antigenic or not, a hitherto unreported phenomenon was noticed. Injection (a provocative injection) of muramyl dipeptide (MDP) caused severe inflammation, with hemorrhage and necrosis in the footpads of guinea pigs, where tubercle bacilli in water-oil emulsion (a preparatory injection) had been injected 3-8 wk earlier. Sometimes the reaction was accompanied by generalized and fatal shock. Several related substances were tested, and only a combination of tubercle bacilli, or MDP plus proteins as the preparatory injection, and MDP as the provocative injection was found to induce this inflammatory necrotic reaction. Development of delayed hypersensitivity to protein antigens may be important for priming, but MDP and not the protein antigens provoked the reaction. This reaction was, so far, only observed in guinea pigs. Although this reaction appears to be similar to the Shwartzman reaction, the two reactions were found to differ from each other in several important points.
在旨在确定胞壁酰二肽（MDP）是否具有抗原性的研究过程中，注意到了一种迄今未报道的现象。给豚鼠注射（激发注射）胞壁酰二肽（MDP）会引起严重炎症，在3至8周前已注射水油乳剂中的结核杆菌（预备注射）的豚鼠脚垫中出现出血和坏死。有时该反应会伴有全身性致命休克。对几种相关物质进行了测试，结果发现只有结核杆菌组合，或作为预备注射的MDP加蛋白质，以及作为激发注射的MDP会引发这种炎性坏死反应。对蛋白质抗原迟发型超敏反应的发展可能对启动反应很重要，但引发该反应的是MDP而非蛋白质抗原。到目前为止，这种反应仅在豚鼠中观察到。尽管这种反应似乎与施瓦茨曼反应相似，但发现这两种反应在几个重要方面彼此不同。
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