1Eye Clinic for Animals, Sydney, NSW, Australia.
2University of Sydney, Camden, NSW, Australia.
J Am Vet Med Assoc. 2024 Sep 13;262(12):1-6. doi: 10.2460/javma.24.02.0140. Print 2024 Dec 1.
To investigate parasiticide use and describe signalment features in patients with sudden acquired retinal degeneration syndrome (SARDS).
Retrospective case-control study of dogs with (n = 71) and without (136) SARDS.
Parasiticide use, presentation season, weight, body condition, and signalment were compared between dogs diagnosed with SARDS and the reference population by use of descriptive statistics and logistic regression.
Animals with SARDS were at a 5.99 times higher odds of having previously used imidacloprid (95% CI, 1.6 to 22.2; P = .003). However, time of last imidocloprid administration was > 6 years prior to diagnosis in 6 SARDS-affected individuals and 15, 26, or 42 months before diagnosis (n = 1 each). No other class of parasiticide had a significant association with SARDS. Seasonal variation was observed with a negative association identified between incidence of SARDS and tick season (October to January; P < .001). Overweight and obese dogs were 4.42 (95% CI, 1.9 to 10.4) and 4.96 (95% CI, 2.1 to 11.6) times more likely to have SARDS (P ≤ .001). History of polyphagia or weight gain was not associated with an increased likelihood of being overweight or obese within the SARDS-affected population (P > .108).
While a statistically significant association was found between imidacloprid use and SARDS, this is unlikely to be clinically significant given the lack of a temporal association, sparse exposure numbers, and low point estimate of the OR. A positive association between being overweight or obese and a diagnosis of SARDS was found independent of polyphagia and weight gain, suggesting that it may be a risk factor for the development of SARDS.
研究杀寄生虫剂的使用情况，并描述突然获得性视网膜变性综合征（SARDS）患者的特征。
对 71 只患有 SARDS 的犬（病例组）和 136 只未患有 SARDS 的犬（对照组）进行回顾性病例对照研究。
使用描述性统计和逻辑回归比较诊断为 SARDS 的犬与参考人群之间的杀寄生虫剂使用、就诊季节、体重、体况和特征。
患有 SARDS 的动物使用过噻虫啉的可能性高 5.99 倍（95%置信区间，1.6 至 22.2；P=.003）。然而，在 6 例 SARDS 受影响个体和 15、26 或 42 个月（各 1 例）前最后一次使用噻虫啉时，时间超过 6 年。没有其他类别的杀寄生虫剂与 SARDS 有显著关联。观察到季节性变化，SARDS 的发生率与蜱季节（10 月至 1 月）呈负相关（P <.001）。超重和肥胖犬患 SARDS 的可能性分别为 4.42（95%置信区间，1.9 至 10.4）和 4.96（95%置信区间，2.1 至 11.6）倍（P ≤.001）。在 SARDS 受影响的犬群中，多食或体重增加与超重或肥胖的可能性增加无关（P >.108）。
虽然发现噻虫啉的使用与 SARDS 之间存在统计学显著关联，但鉴于缺乏时间关联、暴露数量稀少以及 OR 的低值估计，这种关联不太可能具有临床意义。超重或肥胖与 SARDS 的诊断之间存在正相关，与多食和体重增加无关，这表明它可能是 SARDS 发展的一个风险因素。
