普萘洛尔对健康志愿者甲状腺稳态的影响。
Effect of propranolol on thyroid homeostasis of healthy volunteers.
作者信息
Wilkins M R, Franklyn J A, Woods K L, Kendall M J
出版信息
Postgrad Med J. 1985 May;61(715):391-4. doi: 10.1136/pgmj.61.715.391.
The effect of propranolol on thyroid status was investigated by administering the drug in 2 therapeutic doses (80 mg b.d. and 120 mg b.d.) to 8 healthy volunteers and serially measuring total and free thyroid hormones and their major binding protein. Mean free T3 fell by 1.2 pmol/l (P less than 0.05) whilst mean free T4 and mean rT3 rose by 3.3 pmol/l (P less than 0.01) and 0.16 nmol/l (P less than 0.01) respectively. Mean thyroxine binding globulin (TBG) fell by 1.2 mg/l (P less than 0.001). Despite the change in free hormone levels there was no significant change in TSH. For the first time the effect of propranolol on circulating thyroid hormones and binding proteins in healthy subjects is apparent within one study. The biological significance of the change in free hormone levels is discussed.
通过对8名健康志愿者给予两种治疗剂量（每日两次，每次80毫克和每日两次，每次120毫克）的普萘洛尔，并连续测量总甲状腺激素、游离甲状腺激素及其主要结合蛋白，研究了普萘洛尔对甲状腺状态的影响。平均游离T3下降了1.2皮摩尔/升（P<0.05），而平均游离T4和平均反T3分别上升了3.3皮摩尔/升（P<0.01）和0.16纳摩尔/升（P<0.01）。平均甲状腺素结合球蛋白（TBG）下降了1.2毫克/升（P<0.001）。尽管游离激素水平发生了变化，但促甲状腺激素（TSH）没有显著变化。在一项研究中首次明确了普萘洛尔对健康受试者循环甲状腺激素和结合蛋白的影响。讨论了游离激素水平变化的生物学意义。
Zotero 插件