Department of Nutrition and Food Hygiene, School of Public Health, Dalian Medical University, Dalian 116044, China.
School of Public Health, Dalian Medical University, Dalian 116044, China.
Int J Mol Sci. 2024 Sep 2;25(17):9526. doi: 10.3390/ijms25179526.
Nicotinamide adenine dinucleotide (NAD) is an essential metabolite that plays a crucial role in diverse biological processes, including energy metabolism, gene expression, DNA repair, and mitochondrial function. An aberrant NAD level mediates the development of cardiovascular dysfunction and diseases. Both in vivo and in vitro studies have demonstrated that nicotinamide mononucleotide (NMN), as a NAD precursor, alleviates the development of cardiovascular diseases such as heart failure, atherosclerosis, and myocardial ischemia/reperfusion injury. Importantly, NMN has suggested pharmacological activities mostly through its involvement in NAD biosynthesis. Several clinical studies have been conducted to investigate the efficacy and safety of NMN supplementation, indicating its potential role in cardiovascular protection without significant adverse effects. In this review, we systematically summarize the impact of NMN as a nutraceutical and potential therapeutic drug on cardiovascular diseases and emphasize the correlation between NMN supplementation and cardiovascular protection.
烟酰胺腺嘌呤二核苷酸（NAD）是一种必需的代谢物，在多种生物过程中发挥着关键作用，包括能量代谢、基因表达、DNA 修复和线粒体功能。异常的 NAD 水平介导了心血管功能障碍和疾病的发展。体内和体外研究都表明，烟酰胺单核苷酸（NMN）作为 NAD 的前体，可缓解心力衰竭、动脉粥样硬化和心肌缺血/再灌注损伤等心血管疾病的发展。重要的是，NMN 通过参与 NAD 生物合成发挥其药理学作用。已经进行了几项临床研究来调查 NMN 补充的疗效和安全性，表明其在心血管保护方面具有潜在作用，且没有明显的不良反应。在这篇综述中，我们系统地总结了 NMN 作为一种营养保健品和潜在治疗药物对心血管疾病的影响，并强调了 NMN 补充与心血管保护之间的相关性。
