School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
School of Life Sciences, Hainan University, Haikou 570228, China.
Int J Mol Sci. 2024 Sep 6;25(17):9655. doi: 10.3390/ijms25179655.
(Thunb.) (Kidney tea) is a very distinctive ethnic herbal medicine in China. Its leaves are widely used as a healthy tea. Many previous studies have demonstrated its various longevity-promoting effects; however, the safety and specific health-promoting effects of () as a dietary supplement remain unclear. In order to understand the effect of on the longevity of (), we evaluated its role in ; water extracts (CSw) were analyzed for the major components and the effects on were investigated from physiological and biochemical to molecular levels; CSw contain significant phenolic components (primarily rosmarinic acid and eugenolinic acid) and flavonoids (primarily quercetin and isorhamnetin) and can increase the lifespan of . Further investigations showed that CSw modulate stress resistance and lipid metabolism through influencing DAF-16/FoxO (DAF-16), Heat shock factor 1 (HSF-1), and Nuclear Hormone Receptor-49 (NHR-49) signalling pathways; CSw can improve the antioxidant and hypolipidemic activity of and prolong the lifespan of (with the best effect at low concentrations). Therefore, the recommended daily use of should be considered when consuming it as a healthy tea on a daily basis.
(Thunb.) (肾茶)是中国一种非常独特的民族草药。它的叶子被广泛用作健康茶。许多以前的研究表明它具有各种延年益寿的作用;然而，作为膳食补充剂的 ()的安全性和特定的健康促进作用尚不清楚。为了了解对长寿的影响，我们评估了它在中的作用;分析了水提取物 (CSw) 的主要成分，并从生理生化到分子水平研究了其对的影响;CSw 含有显著的酚类成分(主要是迷迭香酸和丁香酸)和类黄酮(主要是槲皮素和异鼠李素)，可以延长的寿命。进一步的研究表明，CSw 通过影响 DAF-16/FoxO (DAF-16)、热休克因子 1 (HSF-1) 和核激素受体-49 (NHR-49)信号通路来调节应激抵抗和脂质代谢;CSw 可以提高的抗氧化和降血脂活性，并延长的寿命(在低浓度时效果最佳)。因此，当将其作为日常健康茶饮用时，应考虑每天推荐的使用量。
