Mitura-Lesiuk Małgorzata Monika, Dubaj Maciej, Dembowska Aleksandra, Bigosiński Karol, Raniewicz Mateusz
Department of Paediatric Haematology, Oncology, and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.
Student Scientific Society of the Department of Paediatric Haematology, Oncology, and Transplantology, Medical University of Lublin, 20-093 Lublin, Poland.
J Clin Med. 2024 Sep 1;13(17):5185. doi: 10.3390/jcm13175185.
: Hyperleukocytosis, defined as a total leukocyte count of more than 50,000/mm leukocytes, occurs in almost one in five children with acute lymphoblastic leukemia (ALL). It represents an unfavorable prognostic factor in this disease. The aim of the following study was to describe demographic and clinical features in patients with hyperleukocytosis and their relationship with leukocyte count. : We retrospectively analyzed the available medical data of patients with ALL diagnosed and treated at the University Children's Hospital in Lublin between 2017 and 2024. : Of the 97 patients, 10 (10.3%) had hyperleukocytosis. They were significantly more likely to be older boys diagnosed with T-ALL. The group with hyperleukocytosis had a higher mortality rate. The presence of hyperleukocytosis also correlated with the presence of petechiae, thrombocyte and neutrophil counts, and LDH activity. Patients with hyperleukocytosis also experienced a higher incidence of infections as a complication of therapy as leukocyte counts increased. : Hyperleukocytosis, although rare, is an important factor in the course of ALL, both clinically and prognostically.
高白细胞血症定义为白细胞总数超过50,000/mm³白细胞，在近五分之一的急性淋巴细胞白血病（ALL）儿童中出现。它是这种疾病的一个不良预后因素。以下研究的目的是描述高白细胞血症患者的人口统计学和临床特征及其与白细胞计数的关系。我们回顾性分析了2017年至2024年期间在卢布林大学儿童医院诊断和治疗的ALL患者的可用医疗数据。在97名患者中，10名（10.3%）有高白细胞血症。他们更有可能是被诊断为T-ALL的年龄较大的男孩。高白细胞血症组的死亡率更高。高白细胞血症的存在还与瘀点、血小板和中性粒细胞计数以及乳酸脱氢酶活性有关。随着白细胞计数增加，高白细胞血症患者作为治疗并发症的感染发生率也更高。高白细胞血症虽然罕见，但在ALL的病程中，无论是临床上还是预后方面，都是一个重要因素。
