College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing, China.
College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2025 Jan 15;325:125077. doi: 10.1016/j.saa.2024.125077. Epub 2024 Sep 5.
This study presents a long-wavelength fluorescent probe CNC for the detection of ClO in vitro and in vivo. Upon interaction with ClO, this probe exhibited a significant increase in fluorescence, with a significant Stokes shift (169 nm), lower detection limit (1.38 μM), high sensitivity and selectivity. Moreover, the probe demonstrated excellent cell permeability and minimal cytotoxicity, allowing for successful imaging of both endogenous and exogenous ClO in living cells.
本研究提出了一种用于体外和体内检测 ClO 的长波长荧光探针 CNC。与 ClO 相互作用后，该探针的荧光显著增强，具有显著的斯托克斯位移（169nm）、更低的检测限（1.38μM）、高灵敏度和选择性。此外，该探针表现出优异的细胞通透性和最小的细胞毒性，可成功地对活细胞内的内源性和外源性 ClO 进行成像。
